脓毒症抗凝策略选择

The strategy of anticoagulant therapy for sepsis

脓毒症是高病死率的临床综合征,在脓毒症患者中常合并凝血功能过度激活,凝血因子大量消耗、微血栓广泛形成导致继发性纤溶亢进还可引发弥散性血管内凝血(DIC),最终病死率进一步升高。以往脓毒症的治疗主要集中于病原微生物的清除及炎症的控制,但难以降低脓毒症病死率。重视脓毒症凝血功能监测,合理选择抗凝治疗人群和时机,可为脓毒症治疗提供新的方向。本文就脓毒症凝血功能障碍抗凝治疗策略进行综述。

The sepsis is the life-threatening organ dysfunction,overactivation of coagulation is often associated with sepsis;continuing consumption of coagulation factors and extensive formation of microthrombus may cause hyperfibrinolysis and carry risk for overt disseminated intravascular coagulation.In clinical practice,the administration of sepsis is central to the antimicrobials,but patients with sepsis still have a high mortality rate.Paying attention to monitoring coagulation in sepsis,reasonable selection of anticoagulation therapy can provide a new direction for the treatment of sepsis.This article reviews the sepsis coagulopathy related testing method and therapy.