新疆喀什地区维吾尔族成年居民糖尿病发病风险及影响因素

Incidence and associated risk factors of diabetes mellitus among Uygur adult residents in Kashgar of South Xinjiang

目的了解新疆喀什地区维吾尔族人群2.5年糖尿病累积发病率及其影响因素,为糖尿病预防提供依据。方法基于队列研究,采用分层整群抽样的方法随机抽取该地区18岁以上常住居民进行问卷调查、体格检查和生化检测。采用非条件Logistic回归分析影响糖尿病发病的危险因素。结果纳入对象3488例,随访2.5年,新发DM 485例,累积发病率为13.9%,年平均发病率为5.6%;基线血糖正常在随访后转化为空腹血糖受损和糖尿病累积发病率分别为8.7%(271/3104)和13.8%(427/3104)。多因素分析显示,年龄≥56岁是男性糖尿病发病独立危险因素;低高密度密度脂蛋白血症可能增加女性糖尿病发病风险(OR=1.51,95%CI:1.17~1.96)。结论新疆维吾尔族人群糖尿病发病率较高,年龄和低高密度脂蛋白血症是主要危险因素,今后应加强对该人群生活习惯和膳食模式的干预,预防糖尿病发生。

Objective To investigate the 2.5 years-cumulative incidence of diabetes mellitus(DM)and analyze the related influential factors in Uygur residents in Kashgar area of South Xinjiang.Methods A cohort study was conducted among the Uygur residents aged 18 years or over who were selected through cluster random sampling in Kashgar area of South Xinjiang.Questionnaire survey,physical examination and basic laboratory test were performed for each subject.Unconditional logistic regression was applied to explore the risk factors.Results The 2.5-year cumulative incidence of DM was 13.9%,representing an annual incidence rate of around 5.6%.And the incidence from normal glucose participants to impaired fasting blood glucose and DM were 8.7%(271/3104)and 13.8%(427/3104)respectively.Multiple logistic regression analysis indicated that age of 56 years old could be risk factors for DM among male population.And low high triglyceride level was the independent risk factors for female populations(OR=1.51,95%CI:1.17-1.96).Conclusions The incidence of diabetes in Xinjiang Uygur population was high.Age and low-density lipoproteinemia were the main risk factors.In the future,interventions on lifestyle habits and dietary patterns should be strengthened to prevent diabetes.