维生素A联合硫酸亚铁治疗反复呼吸道感染对患儿炎性因子及免疫功能的影响

Influence of vitamin A combined with ferrous sulfate on inflammatory factors and immune function in children with repeated respiratory tract infection

目的探讨维生素A联合硫酸亚铁治疗反复呼吸道感染(RRTI)对患儿炎性因子及免疫功能的影响。方法选取200例RRTI患儿,按随机数字表法分为实验组和对照组,每组100例。对照组给予常规抗感染治疗(阿奇霉素颗粒口服,每次0.25 g,每天1次),实验组在此基础上给予维生素A联合硫酸亚铁治疗,两组均连续服用6个月。比较两组患儿治疗前后血清炎性因子水平及免疫功能变化、治疗后临床症状缓解时间及治疗期间不良反应发生情况。结果与治疗前比较,治疗后两组患儿血清白细胞介素-1β(IL-1β)、IL-2、IL-8、IL-10及肿瘤坏死因子-α(TNF-α)水平均明显降低(P<0.01),且实验组明显低于对照组(P<0.01)。与治疗前比较,治疗后两组患儿血清IgA、IgM、IgG水平及CD3+、CD4+比例、CD4+/CD8+均明显升高,且实验组明显高于对照组(P<0.05);两组CD8+比例明显下降,且实验组明显低于对照组(P<0.05)。与对照组比较,实验组患儿治疗后咳嗽、扁桃体红肿、流涕及发热等症状缓解时间明显缩短(P<0.05)。两组总不良反应发生率差异无统计学意义(P>0.05)。结论维生素A联合硫酸亚铁可明显降低RRTI患儿血清致炎因子水平,改善患儿机体免疫功能,有效缓解临床症状,且并未增加不良反应的发生,安全有效,建议临床推广应用。

Objective To investigate the influence of vitamin A combined with ferrous sulfate on inflammatory factors and immune function in children with repeated respiratory tract infection(RRTI).Methods 200 cases of children with RRTI were selected and divided into the experimental group and the control group according to the random number table method,100 cases in each group.The control group was given conventional anti-infective treatment,and the experimental group was given vitamin A combined with ferrous sulfate treatment,the two groups were treated continuously for 6 months.The levels of serum inflammatory factors and immune function,the clinical symptom relief time after treatment and adverse reactions during the treatment were compared before and after treatment in the two groups.Results Compared with before treatment,the levels of serum IL-1β,IL-2,IL-8,IL-10 and TNF-αsignificantly decreased after treatment in the two groups(P<0.01),and the experimental group was significantly lower than the control group(P<0.01).Compared with before treatment,the levels of serum IgA,IgM,IgG,the ratio of CD3+,CD4+and CD4+/CD8+significantly increased after treatment in the 2 groups,and the experimental group was significantly higher than the control group(P<0.05);the ratio of CD8+significantly decreased in the two groups,and the experimental group was significantly lower than the control group(P<0.05).Compared with the control group,the symptoms of cough,tonsil swelling,salivation and fever significantly shortened in the experimental group(P<0.05).There was no significant difference in the incidence of total adverse reactions between the two groups(P>0.05).Conclusion Vitamin A combined with ferrous sulfate could significantly reduce the levels of serum inflammatory factors in children with RRTI,improve the immune function of children,effectively relieve clinical symptoms,and does not increase the incidence of adverse reactions.This treatment was safe and effective,and it should be recommended to promote clinical application.