锌指蛋白在急性白血病中的研究进展

Progress of zinc finger proteins in acute leukemia

目的总结锌指蛋白(ZFPs)在急性白血病发生发展中的生物学功能以及在急性白血病患者预后中的意义,以期为临床研究提供借鉴。方法以“锌指蛋白、急性白血病、急性淋巴细胞白血病、急性髓细胞白血病”为中文关键词,以“zinc finger proteins,acute leukemia,acute lymphoblastic leukemia,acute myeloid leukemia”为英文关键词,检索中国知网、PubMed以及万方数据库2003-01-01-2023-12-31发表的相关文献。纳入标准:(1)ZFPs在急性白血病中生物学功能的研究;(2)ZFPs在急性白血病中表达及预后关系的研究。排除标准:(1)数据不完整的文献;(2)质量差的文献。根据纳入标准分析文献63篇。结果ZFPs可通过下调抑癌基因p53表达,促进急性白血病细胞增殖;沉默急性白血病细胞株ZEB2、ZBTB46基因,细胞生长受到明显抑制。ZFPs通过调控细胞周期蛋白p21、p27、Cyc-A2表达,使急性白血病细胞周期阻滞在G_(0)/G_(1)期或S期。ZFPs通过影响凋亡相关蛋白Bcl-2、Bax、Bcl-xl表达,促进或抑制急性白血病细胞凋亡。ZFPs对维持ESCs和LSCs自我更新具有重要作用。ZFPs表达异常是判断急性白血病患者预后和生存的潜在指标。结论ZFPs可通过影响细胞增殖、细胞凋亡、细胞周期、白血病干细胞等参与急性白血病的发生发展,对急性白血病临床预后具有重要指导意义。

Objective To summarize the biological functions and prognostic significance of zinc finger proteins(ZFPs)in acute leukemia,in order to provide useful references for clinical research.Methods The relevant literature included in CNKI,Pubmed and Wanfang databases from January 1,2003 to December 31,2023 were retrieved with the keywords"zinc finger proteins,acute leukemia,acute lymphoblastic leukemia,and acute myeloid leukemia".Inclusion criteria:(1)Research on the biological function of ZFPs in acute leukemia;(2)Research on the expression and prognostic relationship of ZFPs in acute leukemia.Exclusion criteria:(1)Literature with incomplete data;(2)Low quality literature.Finally,63 articles were included for analysis.Results ZFPs can promote the proliferation of acute leukemia cells by down-regulating the expression of the p53 gene;Silencing the ZEB2 and ZBTB46 gene in the acute leukemia cell line can inhibits cell growth significantly.ZFPs inhibits the cell cycle of acute leukemia in G_(0)/G_(1)or S phases by regulating cell cycle proteins(p21,p27 and Cyc-A2).ZFPs promote or inhibit acute leukemia cells'apoptosis by affecting apoptosis-related proteins(Bcl-2,Bax and Bcl-xl)expression.ZFPs play an important role in maintaining self-renewal of ESCs and LSCs.Abnormal expression of zinc finger proteins is a potential indicator for predicting the prognosis and survival rate of acute leukemia patients.Conclusion ZFPs promote the occurrence and development of acute leukemia by affecting cell proliferation,apoptosis,cell cycle,and leukemia stem cells.It has a great significance for the clinical prognosis of acute leukemia.