研究对比氯沙坦与氨氯地平治疗原发性高血压对患者血管内皮功能和生活质量的影响

Research on the Effects of Losartan and Amlodipine on Vascular Endothelial Function and Quality of Life in Patients with Essential Hypertension

目的比较原发性高血压采用氨氯地平、氯沙坦治疗后对患者生活质量及血管内皮功能的影响。方法通过双盲法分组标准将广西医科大学附属肿瘤医院2017年11月—2019年2月接收的122例原发性高血压患者分为对照组和研究组,对照组(n=61)采用氨氯地平治疗,研究组(n=61)采用氯沙坦治疗。比较两组治疗效果。结果治疗后,两组总疗效接近,比较差异无统计学意义(P>0.05);研究组血压水平、血管内皮功能和生活质量评分均优于对照组,差异有统计学意义(P<0.05)。结论原发性高血压患者临床治疗中采用氯沙坦或氨氯地平均可取得良好效果,但氯沙坦的作用更显著,优于氨氯地平,值得采纳。

Objective To compare the effects of amlodipine and losartan on quality of life and vascular endothelial function in patients with essential hypertension.Methods 122 patients with essential hypertension received in Guangxi Medical University Affiliated Tumor Hospital from November 2017 to February 2019 were divided into control group and research group according to the double blind method.The control group(n=61)was treated with amlodipine and the research group(n=61)was treated with losartan.The therapeutic effects of the two groups were compared.Results After treatment,the total curative effect of the two groups was close,P>0.05,without statistical difference;the blood pressure level,vascular endothelial function and quality of life score of the study group were better than those of the control group,P<0.05,with statistical difference.Conclusion Losartan or amlodipine can achieve good results in the clinical treatment of essential hypertension patients,but the effect of losartan is more significant than amlodipine,which is worth adopting.