多索茶碱联合噻托溴铵方案治疗尘肺的效果观察

Observation of the effect of doxofylline combined with tiotropium bromide in the treatment of pneumoconiosis

目的观察多索茶碱联合噻托溴铵方案治疗尘肺的效果。方法选取2017年6月-2018年5月四川省邻水县人民医院和四川省安岳县人民医院呼吸内科接收的尘肺患者94例,根据随机数字表法分为观察组和对照组各47例。2组均接受常规对症治疗,对照组在其基础上加用多索茶碱,观察组联合应用多索茶碱联合噻托溴铵。将2组患者的临床效果、肺功能、白细胞和中性粒细胞进行比对。结果观察组患者的临床总有效率为95.74%,高于对照组的80.85%(χ2=5.045,P<0.05)。观察组患者治疗后的FVC、FEV1、FEV1/FVC及MVV均高于治疗前及对照组,对照组治疗后FEV1、MVV高于治疗前(P均<0.05)。治疗后,2组患者的白细胞计数和中性粒细胞计数均低于治疗前,且观察组患者均低于对照组(P<0.05)。结论多索茶碱联合噻托溴铵方案能较好地促进尘肺患者症状转归,有利于患者肺功能的改善及减轻肺部炎性反应。

Objective To observe the effect of doxofylline combined with tiotropium bromide in the treatment of pneumoconiosis.Methods 94 cases of pneumoconiosis patients,received from the Department of Respiratory Medicine of the People’s Hospital of Linshui County and the People’s Hospital of Anyue County,from June 2017 to May 2018 were selected.According to the random number table method,they were divided into observation group and control group,each of 47 cases.The clinical effects,pulmonary function,leukocytes and neutrophils were compared between the two groups.Both groups received conventional symptomatic treatment,the control group was added with doxofylline,and the observation group was combined with doxofylline and tiotropium bromide.The clinical effects,lung function,white blood cells and neutrophils count of the two groups of patients were compared.Results The total clinical effective rate of patients in the observation group was95.74%,higher than 80.85%in the control group(χ2=5.045,P<0.05).After treatment,the FVC,FEV1,FEV1/FVC,and MVV in the observation group were higher than before treatment and the control group,and FEV1,MVV in the control group were higher than before treatment(P<0.05).After treatment,the white blood cell count and neutrophil count of the two groups were lower than before treatment,and the observation group was lower than the control group(P<0.05).Conclusion Doxotheophylline combined with tiotrobromide regimen can improve the symptoms of pneumoconiosis patients,improve the pulmonary function and reduce the inflammatory reaction of the lungs.