美托洛尔治疗充血性心力衰竭的临床疗效

Clinical effect of metoprolol in the treatment of congestive heart failure

目的探讨美托洛尔治疗充血性心力衰竭(CHF)的临床疗效。方法选取常州市金坛区人民医院2017年2月—2019年2月收治的CHF患者86例,根据入院顺序奇偶性分为对照组和研究组,各43例。对照组给予常规治疗,研究组在对照组基础上给予美托洛尔片治疗,两组均连续治疗2个月。比较两组临床疗效,治疗前后心功能指标〔左心室射血分数(LVEF)、左心室收缩末期内径(LVESD)、左心室舒张末期内径(LVEDD)〕及N末端B型利钠肽前体(NT-proBNP)。结果研究组总有效率高于对照组(P<0.05)。治疗前两组LVEF、LVESD、LVEDD比较,差异无统计学意义(P>0.05);治疗后研究组LVEF高于对照组,LVESD、LVEDD低于对照组(P<0.05)。治疗前两组NT-proBNP比较,差异无统计学意义(P>0.05);治疗后研究组NT-proBNP高于对照组(P<0.05)。结论美托洛尔治疗CHF的临床疗效确切,可减轻呼吸困难等临床症状,改善心功能。

Objective To explore the clinical effect of metoprolol on congestive heart failure(CHF).Methods A total of 86 cases of patients with CHF were selected from February 2017 to February 2019 in Changzhou Jintan District People’s Hospital,which were divided into control group and study group according to the parity of admission sequence,43 cases each of group.The control group was given conventional treatment,and the study group was given metoprolol tablets based on the control group.Both groups were treated for 2 months.Clinical efficacy,the indexes of cardiac function(LVEF,LVESD,LVEDD)and NT pro-BNP before and after treatment were compared.Results The total effective rate of the study group was higher than the control group(P<0.05).There was no significant difference in LVEF,LVESD and LVEDD between the two groups before treatment(P>0.05);after treatment,the study group of LVEF was higher than the control group,LVESD and LVEDD were lower than the control group(P<0.05).There was no significant difference in NT pro-BNP between the two groups before treatment(P>0.05);after treatment,the study group of NT pro-BNP was higher than the control group(P<0.05).Conclusion Metoprolol has definite clinical effect on CHF,it can reduce the clinical symptoms of dyspnea and improve the heart function.