基于文献探讨马鞭草对新型冠状病毒肺炎的作用机制

Mechanism discussion of verbena officinalis L. against COVID-19 based on the literatures

全球暴发的新型冠状病毒肺炎(coronavirus disease 2019,COVID-19)传染性强,潜伏期久,人群普遍易感,对人类生命健康造成了巨大威胁。我国采用中西医结合辨证、分期论治COVID-19,临床效果显著,又一次凸显了祖国医学在疫病(传染性疾病)防治中的重要作用。药理学实验和临床实践证明马鞭草具有免疫调节、抗炎、抗病毒和镇咳作用,对机体免疫功能低下、肺炎、慢性前列腺炎等多种炎症和病毒性疱疹、乙型肝炎、丙型肝炎等病毒性肝炎等有确切疗效。现基于文献对马鞭草免疫调节、抗炎、抗病毒、镇咳的药效物质、药理作用和临床应用进行总结梳理,多个角度探讨马鞭草对COVID-19的作用机制,以期为临床治疗COVID-19和后续相关药物研发提供参考依据。

Coronavirus disease 2019(COVID-19)is highly infectious with a long incubation period,and generally susceptible to the population,which poses a great threat to the life and health of people all over the world.At present,the combination of traditional Chinese medicine and Western medicine and dialectical treatment for COVID-19 obtained the significant clinical efficacy in China,which once again highlights the important role of Chinese medicine in the prevention and treatment of epidemics(infectious diseases).Pharmacological experiments and clinical practice have proved that verbena officinalis L.has immunoregulation,anti-inflammatory,antiviral and antitussive effects,and definite curative efficacy on hypoimmunity,pneumonia,chronic prostatitis,and other inflammations,such as low immune function,pneumonia,chronic prostatitis and viral herpes,hepatitis B and hepatitis C.In this paper,we summarized the pharmacodynamic substances,pharmacological effects and clinical applications of verbena officinalis L.based on the literatures,and discussed the possible mechanism of verbena officinalis L.in preventing and treating COVID-19 from multiple angles so as to provide a reference for clinical prevention and treatment of COVID-19 and subsequent research and development of related drugs.