肺肉瘤样癌的临床和分子生物学研究进展

Advances in the clinical research and molecular biology of pulmonary sarcomatoid carcinoma

肺肉瘤样癌是一种由上皮组织和间叶组织混合形成的恶性肿瘤,代表了上皮和间充质分化的整体连续谱系,是肺癌的一种罕见亚型,具有独有的特征。由于其发病率低,临床和病理医师对于其诊断和治疗常常会遇到困难。目前关于其临床特征、治疗策略和预后的研究还不充分,尤其是近年来发展起来的靶向治疗、免疫治疗在肺肉瘤样癌中的应用少有报道。现就肺肉瘤样癌的临床和分子生物学特征进行综述,目的是使广大临床医师充分了解肺肉瘤样癌的临床和分子生物学特征,以便更好地决定治疗方案,改善患者预后。

Pulmonary sarcomatoid carcinoma is a kind of malignant tumor formed by the mixture of epithelial tissue and mesenchymal tissue.It represents the whole continuous lineage of epithelial and mesenchymal differentiation.It is a rare subtype of lung cancer with unique characteristics.Because of its low incidence,clinicians and pathologists often encounter difficulties in its diagnosis and treatment.At present,the research on its clinical characteristics,treatment strategies and prognosis is not enough.In particular,the application of targeted therapy and immunotherapy in it is rarely reported.The clinical and molecular characteristics of pulmonary sarcomatoid carcinoma were reviewed in this article.The aim is to make the clinical and molecular characteristics of pulmonary sarcomatoid carcinoma fully understood so as to better determine the treatment plan and improve the prognosis of patients.