奥氮平与氨磺必利治疗精神分裂症的对照疗效分析

Comparative Analysis of Olanzapine and Amisapride in the Treatment of Schizophrenia

目的比较奥氮平与氨磺必利治疗精神分裂症的临床效果。方法选择医院84例精神分裂症患者,随机分为A、B两组。A组予以奥氮平治疗,B组予以氨磺必利治疗。对比两组治疗效果及不良反应发生状况。结果B组治疗总有效率与A组相比,无明显差异(P>0.05);B组嗜睡、泌乳与月经改变、体质量增加发生率分别为2.38%、7.14%、2.38%,明显低于A组的19.05%、23.81%、21.43%,两组之间存在显著差异(P<0.05)。结论在治疗精神分裂症方面,奥氮平和氨磺必利均可达到较好效果,但相较于奥氮平,氨磺必利的不良反应较小。

Objective To compare the clinical effects of olanzapine and amisapride in the treatment of schizophrenia.Methods Eighty-four patients with schizophrenia in our hospital were randomly divided into two groups:group A was treated with olanzapine and group B was treated with azepripine.The therapeutic effect and adverse reactions were compared between the two groups.Results There was no significant difference in the total effective rate between group B and group A(P>0.05).The incidence of drowsiness,lactation and menstrual changes,and weight gain in group B were 2.38%,7.14%,and 2.38%,respectively.There were 19.05%,23.81%,and 21.43%in group A,and there was a significant difference between the two groups(P<0.05).Conclusion Olanzapine and amisapride can achieve better results in the treatment of schizophrenia,but the adverse reactions of olanzapine are less than olanzapine.