胰体尾联合血管切除重建手术治疗晚期胰腺癌

Pancreatic Body and Tail Combined With Vascular Resection and Reconstruction for Advanced Pancreatic Cancer

目的探讨晚期胰腺癌胰体尾联合血管切除重建手术配合化疗的治疗效果。方法回顾性分析本院2016年1月—2018年3月期间诊治的58例晚期胰腺癌患者临床资料。本组研究对象均实行化疗干预,依据手术方案分组:将单纯进行化疗干预者设为对照组(n=29),将采取胰体尾联合血管切除重建手术配合化疗者设为研究组(n=29),就两组患者肿瘤控制效果、治疗后一年内生活质量以及中位无进展生存期差异进行统计学分析。结果(1)研究组患者的肿瘤控制有效率高于对照组,差异有统计学意义(χ2=4.549,P=0.033);(2)研究组生活质量评分高于对照组,差异有统计学意义(t=9.048,P=0.003);(3)研究组患者中位无进展生存时间是(11.48±1.18)个月,长于对照组的(9.15±1.45)个月,差异有统计学意义(t=9.159,P=0.001)。结论晚期胰腺癌胰体尾联合血管切除重建手术配合化疗的临床效果更佳,可优化肿瘤控制效果,延长患者中位无进展生存期,并提高其生活质量。

Objective To explore the therapeutic effect of pancreatectomy and revascularization combined with chemotherapy for advanced pancreatic cancer.Methods The clinical data of 58 patients with advanced pancreatic cancer from January 2016 to March 2018 were analyzed retrospectively.The patients in this group were implemented with chemotherapy and divided into two groups according to the operation plan:the control group(n=29)was treated by chemotherapy alone,and the study group(n=29)was treated by pancreaticocery combined with vascular resection and reconstruction combined with chemotherapy.Results(1)The effective rate of tumor control in the study group was higher than that in the control group,the difference was statistically significant(χ2=4.549,P=0.033);(2)the quality of life score in the study group was higher than that in the control group,the difference was statistically significant(t=9.048,P=0.003);(3)the median progression free survival time in the study group was(11.48±1.18)months,longer than that in the control group(9.15±1.45)months,the difference was statistically significant(t=9.159,P=0.001).Conclusion The clinical effect of pancreatectomy and reconstruction combined with chemotherapy is better in advanced pancreatic cancer.It can optimize the effect of tumor control,prolong the median progression free survival period and improve the quality of life of patients.