HIV感染者接种新型冠状病毒疫苗的必要性及免疫效果研究进展

Research progress on the necessity and immune effect of COVID-19 vaccination in HIV-infected patients

目前,接种新型冠状病毒疫苗(简称新冠疫苗)是预防严重急性呼吸综合征冠状病毒2(severe acute respiratory syndrome coronavirus 2,SARS-CoV-2)感染及降低新型冠状病毒肺炎(corona virus disease 2019,COVID-19)重症率、死亡率的重要措施之一。人类免疫缺陷病毒(human immunodeficiency virus,HIV)感染者(HIV infector)是COVID-19的高风险人群,多国疾病预防控制机构和相关学术团体均建议优先为HIV感染者接种新冠疫苗,且已有研究显示HIV感染者接种新冠疫苗后的益处远大于风险。现通过梳理和总结近两年的相关研究,就HIV感染者接种新冠疫苗的必要性、接种效果、影响HIV感染者接种新冠疫苗效果的因素及接种新冠疫苗对HIV感染者的影响等作一概述,以期为HIV感染者新冠疫苗预防接种提供参考。

COVID-19 vaccination is an effective way to prevent severe acute respiratory syndrome coronavirus 2(SARS-COV-2)infection and reduce the severity and mortality rates of corona virus disease 2019(COVID-19).People living with HIV(PLWH)are at high risk of COVID-19,who are recommended to be prioritized for COVID-19 vaccination by health authorities and academic communities across the world.It has been suggested by previous studies that the benefits outweigh the risks for HIV-infected patients to be vaccinated with a COVID-19 vaccine.In this review,we go through relevant studies published in the recent 2 years and summarize the research progresses from four aspects:the necessity of COVID-19 vaccination for PLWH,COVID-19 vaccine effectiveness among PLWH,the factors influencing COVID-19 vaccine effectiveness among PLWH and the impact of COVID-19 vaccination on HIV-infected patients,so as to provide insights into COVID-19 vaccination among PLWH.