肽聚糖的生理功能及其在疾病诊断中的作用进展

Peptidoglycan biological function and related role in diagnosis of disease

肽聚糖(peptidoglycan,PGN)是细菌细胞壁的主要结构,与体内多种受体信号分子如核苷酸结合寡聚化结构域蛋白1/2(nucleotide-binding oligomerization domain protein 1/2,NOD1/2)、Toll样受体2(toll like receptor 2,TLR2)和PGN识别蛋白(peptidoglycan recognition proteins,PGRP)等结合后,参与人体如发烧、睡眠和骨生成等生理功能。研究发现,PGN作为病原微生物细菌的结构成分,在临床血流感染和自身免疫疾病诊断中也发挥着重要作用。现就PGN在人体内的代谢、功能及疾病诊断应用价值作一概述。

Peptidoglycan,as the core and essential element of bacterial cell wall,could be recognized by some receptors including NOD1/2,TLR2 and PGRP.It has an important effect on the physiological function of human body,involved in fever,sleep and osteogenesis.Recent studies have shown that peptidoglycan,as the structural component of pathogen,plays a vital role in the diagnosis of bloodstream infection(BSI)and autoimmune disease.This review mainly focuses on the metabolism,biological function of peptidoglycan in human body,and its possible value in the diagnosis of disease.