正常血清降钙素和大肿块甲状腺髓样癌的研究进展

Progress of study on medullary thyroid carcinoma with serum calcitonin-negative and large mass

甲状腺髓样癌(medullary thyroid carcinoma,MTC)具有侵袭性强、较早出现淋巴结转移及远处转移的特点。在甲状腺肿瘤中,MTC侵袭程度仅次于未分化癌。血清降钙素是检测MTC最敏感的肿瘤标志物,并与肿瘤大小相关。然而,当肿瘤直径>1 cm时,部分MTC病人血清降钙素处于正常范围,给诊断带来困难。本文综述肿瘤直径>1 cm、血清降钙素正常的MTC研究进展。

The characteristics of medullary thyroid carcinoma(MTC)include strong invasiveness,early lymph node metastasis and distant metastasis.MTC is aggresive only less than anaplastic carcinoma in all thyroid malignancies.Serum calcitonin is the most sensitive tumor marker for detecting MTC,which correlates with tumor size.However,it is difficult to diagnose some MTC patients with tumor diameter greater than 1 cm and serum calcitonin negative.This review focuses on recent advances in study on MTC with diameter greater than 1 cm and serum calcitonin negative.