肠道菌群与肝癌的发病机制

Gut microbiota and mechanism of liver cancer

我国肝癌发病率高,新发病例占全球46.7%,死亡病例占47.1%。肝癌发病与肝炎病毒、黄曲霉素、饮酒等危险因素相关。近年对肠道菌群研究日渐深入,显示肠道菌群在肝癌发生、发展中的作用。本文从菌群移位、肠源性内毒素血症和细菌代谢产物变化探讨肝癌与肠道菌群的关系,并从益生菌、粪便菌群移植、抗生素以及Toll样受体4拮抗剂途径探索经肠道菌群治疗肝癌的新思路。

Liver cancer incidence in China is higher with new cancer cases accounted for 46.7%of global prevalence and death cases 47.1%.Hepatic virus,aflatoxin and alcohol drinking are the risk factors associated with the mechanism of liver cancer.Study on gut microbiota in recent years was ongoing deeply,indicating gut microbiota associated with the development of liver cancer.Liver cancer with gut microbiota was studied in this paper for microbiota displacement,intestinal endotoxemia,and changes in bacterial metabolite,including the new ideas in treatment of liver cancer via gut microbiota from probiotics,fecal microbiota transplantation,antibiotics and Toll-like receptor 4 antagonist pathways.