封闭负压引流技术联合贝复新在压力性损伤治疗中的应用

Application of closed negative pressure drainage combined with Beifuxin in treatment of pressure injury

目的探讨封闭负压引流技术联合贝复新治疗压力性损伤的效果。方法选取武警辽宁总队医院2014-01至2022-10压力性损伤患者52例作为研究对象,根据入院顺序编号随机分为观察组(n=26)和对照组(n=26)。两组均在清创术中安置封闭负压引流装置后,对照组予以常规封闭负压引流治疗,观察组予以封闭负压引流技术联合贝复新治疗。观察和比较两组治疗前后疼痛评分(VAS)、压疮评分(Braden),趋化因子SDF-1α和CXCR4表达变化,术后7 d、14 d、21 d创面愈合率等。结果与治疗前相比,两组治疗后VAS评分及Braden评分明显改善,且观察组显著优于对照组(P<0.05);观察组治疗后趋化因子SDF-1α和CXCR4蛋白表达水平明显高于对照组(P<0.05);两组创面愈合率随治疗时间延长而逐渐提升,观察组创面愈合率持续高于对照组(P<0.05);观察组总有效率(92.31%)高于对照组(84.61%),有统计学差异(P<0.05)。结论封闭负压引流技术联合贝复新治疗压力性损伤疗效确切,能更好地促进创面愈合。

Objective To explore the application effect of closed negative pressure drainage combined with Beifuxin in the treatment of pressure injury.Methods Fifty-two patients with stress injury who were hospitalized in Liaoning Provincial Corps Hospital of Chinese People’s Armed Police Force from January 2014 to October 2022 were selected as the research subjects,and randomly divided into observation group(n=26)and control group(n=26)according to the admission sequence number.After the installation of closed negative pressure drainage device in debridement for both groups,the control group was treated with conventional closed negative pressure drainage,and the observation group was treated with closed negative pressure drainage combined with Beifuxin.The levels of pain score(VAS),pressure sore score(Braden),expression of chemokines SDF-1αand CXCR4,and wound healing rate at 7 d,14 d and 21d after surgery were observed and compared between the two groups before and after the treatment.Results VAS score and Braden score in the two groups were significantly improved after treatment,and the observation group was significantly better than the control group(P<0.05).The protein expression levels of SDF-1αand CXCR4 in the observation group were significantly higher than those in the control group after treatment(P<0.05).The wound healing rate of the two groups gradually increased with the prolongation of treatment time,and the wound healing rate of the observation group was consistently higher than that of the control group(P<0.05).The total effective rate of the observation group and the control group was 92.31%and 84.61%respectively,and the therapeutic effect of the observation group was significantly better than that of the control group(P<0.05).Conclusions The technique of closed negative pressure drainage combined with Beifuxin is effective in the treatment of pressure injury,which can better promote wound healing.