雌激素受体α基因SNP12(rs6932902)位点多态性与隐睾相关性的Meta分析

Meta-analysis of the association between estrogen receptor α SNP12 (rs6932902) locus polymorphism and cryptorchidism

目的探讨雌激素受体α基因SNP12(rs6932902)位点多态性与隐睾的关系。方法计算机检索PubMed、Embase、EBSCO、知网、中国生物医学文献数据库、维普及万方数据库(1990-01至2021-05),查找关于激素受体α基因rs6932902多态性与隐睾患病风险的病例对照研究。收集雌激素受体α基因rs6932902多态性与隐睾相关性的相关病例对照研究,应用STATA 12.0软件进行Meta分析,计算合并比值比(OR)及95%可信区间(CI),并进行敏感性分析,以及发表偏倚的评价。结果共纳入4篇病例对照研究,Meta分析结果显示:雌激素受体α基因rs6932902位点多态性与隐睾发生风险相关:基因频率A vs.G[OR=0.987,95%CI(0.594,1.612),P=0.931];显性模型AA+GA vs.GG[OR=0.845,95%CI(0.494,1.446),P=0.539];隐形模型AA vs.GA+AA[OR=1.946,95%CI(1.005,3.767),P=0.048];共显性模型GA vs.GG[OR=0.729,95%CI(0.451,1.180)P=0.198]共显性模型AA vs.GG[OR=1.863,95%CI(0.947,3.663),P=0.071];超显性模型GG+AA vs.GA[OR=1.549,95%CI(1.150,2.209),P=0.005]。结论雌激素受体α基因rs6932902位点多态性与隐睾疾病相关;在隐形遗传或者超显性遗传中,AA基因型或AA+GG基因型可增加隐睾患病的风险。

Objective To explore the relationship between SNP12(rs6932902)polymorphism of estrogen receptorαgene and cryptorchidism.Methods The case-control studies involving the association of estrogen receptorαgene rs6932902 polymorphism with the susceptibility to cryptorchidism were retrieved through computer-based search in PubMed,Embase,EBSCO,CNKI,CBM,VIP and Wan Fang Data(1990.01-2021.05).The statistical analysis was performed by STATA 12.0 software.Pooled odds ratio(OR)and 95%confidence interval(CI)were calculated,and the sensitivity analysis and publication bias were carried out.Results A total of four case-control studies were included for the meta-analysis.The analysis revealed that there was a significant association of estrogen receptorαrs6932902 polymorphism with the risk of cryptorchidism A vs.G[OR=0.987,95%CI(0.594,1.612),P=0.931];dominant model:AA+GA vs.GG[OR=0.845,95%CI(0.494,1.446),P=0.539];recessive model:AA vs.GA+AA[OR=1.946,95%CI(1.005,3.767),P=0.048];co-dominant model:GA vs.GG[OR=0.729,95%CI(0.451,1.180),P=0.198];co-dominant model:AA vs.GG[OR=1.863,95%CI(0.947,3.663),P=0.071];over-dominant:GG+AA vs.GA[OR=1.549,95%CI(1.150,2.209),P=0.005].Conclusions Estrogen receptorαrs6932902 polymorphism may be significantly associated with the susceptibility to cryptorchidism.The AA genotype or AA+GG genotype increases the risk of cryptorchidism in either recessive or super dominant inheritance.