高尔基体磷蛋白3及蛋白激酶D2在肺腺癌中的表达及其临床意义

Clinical significance of GOLPH3 and PKD2 expression in lung adenocarcinoma

目的探讨蛋白激酶D2(PKD2)与高尔基体磷蛋白3(GOLPH3)在肺腺癌中的表达及其临床意义。方法收集联勤保障部队第904医院2014-06至2018-06进行肺癌根治术、术后病理诊断为肺腺癌的106例患者的临床资料。免疫组化检测肺腺癌组织与相应癌旁组织中的GOLPH3及PKD2表达情况。通过log-rank检验以及多因素COX风险回归模型分析肺腺癌患者GOLPH3与PKD2的表达水平以及对患者预后的影响。结果GOLPH3及PKD2在肺腺癌组织中的表达水平明显高于对应癌旁组织(P<0.05)。并且,肺腺癌组织中GOLPH3及PKD2表达水平存在正相关(V=0.363,P<0.05)。单因素分析结果显示GOLPH3及PKD2的表达水平、肿块直径、TNM分期、淋巴转移、组织分化程度会影响患者的预后(P<0.05),多因素分析提示GOLPH3高表达(HR=2.879,95%CI=1.590~5.212,P<0.05),PKD2高表达(HR=1.922,95%CI=1.078~3.427,P<0.05)及TNM分期(HR=2.022,95%CI=1.144~3.573,P<0.05)是影响患者生存的独立危险因素。结论GOLPH3与PKD2在肺腺癌中高表达,并且是影响肺腺癌患者预后的独立危险因素。

Objective To explore the clinical significance of PKD2 and GOLPH3 expression in lung adenocarcinoma.Methods Clinical data of 106 patients with lung adenocarcinoma were collected from June 2014 to June 2018 in the 904 th Hospital of Chinese PLA Joint Logistics support Force.The expression of GOLPH3 and PKD2 in lung adenocarcinoma and corresponding adjacent tissues were detected by immunohistochemistry.The expression levels of GOLPH3 and PKD2 in lung adenocarcinoma tissues and their effects on prognosis were analyzed by log-rank test and multivariate COX risk regression model.Results The expression levels of GOLPH3 and PKD2 in lung adenocarcinoma tissues were significantly higher than those in corresponding adjacent tissues(P<0.05).In addition,there was a positive correlation between the expression of GOLPH3 and PKD2 in lung adenocarcinoma.Univariate analysis showed that the expression of GOLPH3 and PKD2,tumor diameter,TNM stage,lymphatic metastasis and tissue differentiation affected the prognosis of the patients.Multivariate analysis showed high expression of GOLPH3(HR=2.879,95%CI=1.590-5.212,P<0.05),high expression of PKD2(HR=1.922,95%CI=1.078-3.427,P<0.05)and TNM stage(HR=2.022,95%CI=1.144-3.573,P<0.05)were the independent risk factors affecting the survival of patients.Conclusions GOLPH3 and PKD2 which are characterized by high expression in lung adenocarcinoma are the independent risk factors affecting the prognosis of patients with lung adenocarcinoma.