某部驻训期间发热呼吸道综合征病原谱监测分析

Pathogenic spectrum of febrile respiratory syndrome during field training in a military unit

目的了解某部驻训期间发热呼吸道综合征(febrile respliratory syndrome,FRS)病原体种类和流行特征,为有效控制疾病的发生与蔓延提供依据。方法采用回顾性调查和现场流行病学调查方法,对2019-08至2019-11某部驻训期间FRS患者进行问卷调查,利用RT-PCR和PCR方法对FRS病例咽拭子标本进行病毒核酸检测。结果101例FRS病例中,均出现发热症状(≥37.5℃),伴有乏力50例(49.50%)、肌肉酸痛39例(38.61%)、头痛36例(35.64%)、咽痛29例(28.71%)和咳嗽29例(28.71%)等症状;检出阳性标本37例,总阳性率为36.63%,其中流感病毒阳性率(26.73%)最高,其次为人副流感病毒(3.96%)、人呼吸道合胞病毒(2.97%)、人鼻病毒(2.97%)、人偏肺病毒(1.98%);人博卡病毒、人腺病毒、人冠状病毒均未检出。结论某部驻训期间FRS病例中最常见的呼吸道病毒感染为流感病毒,提示应加强疫情监测和防控工作,防止疫情的扩散蔓延。

Objective To analyze the pathogenic species and epidemic characteristics of febrile respiratory syndrome(FRS)during field training,so as to provide scientific basis for prevention and control measures.Methods Epidemiologic,clinical data were collected by interviewing patients and retrieving medical records in a military unit from August to November 2019.Pharyngeal swab specimens were collected from patients with febrile respiratory syndrome and detected by reverse transcription polymerase chain reaction(RT-PCR)and PCR assay for common respiratory tract viruses.Results Among the 101 FRS patients,the clinical manifestations of patients were fever(100.00%),fatigue(50,49.50%),muscle aches(39,38.61%),headache(36,35.64%),sore throat(29,28.71%),and cough(29,28.71%).There were 37 specimens of virus positive,the total positive rate was 36.63%,with influenza virus(IFV)positive rate as the highest(26.73%),followed by human parainfluenza virus(HPIV)(3.96%),respiratory syncytial virus(RSV)(2.97%),human rhinovirus(HRV)(2.97%)and human metapneumovirus(HMPV)(1.98%).No human bocavirus(HBoV),human adenovirus(HAdV)and human coronavirus(HCoV)were detected positive.Conclusion The most common pathogen of FRS was influenza virus during field training i,and it is necessary to reinforce epidemic surveillance to prevent the spread of the disease.