紫癜性肾炎患儿血清PTX3、IgA/C3水平变化及与肾功能损伤的相关性

Changes of serum PTX3 and IgA/C3 levels in patients with Henoch Schonlein purpura nephritis treated with mycophenolate mofetil and prednisone

目的探讨紫癜性肾炎(purpuric nephritis,HSPN)患儿血清正五聚素-3(PTX3)、IgA/C3水平变化及与肾功能损伤的相关性。方法选择医院2014-05至2019-06收治的96例经吗替麦考酚酯与泼尼松联合治疗的HSPN患儿为治疗组,并选取同期来该院体检的80例健康儿童为对照组。观察两组受试者血清免疫球蛋白A(Ig A)、免疫球蛋白G(Ig G)、免疫球蛋白M(Ig M)、补体C3及PTX3水平变化,并计算IgA/C3值,比较两组受试者血清IgA/C3水平及肾功能指标差异,并通过Pearson法对经吗替麦考酚酯与泼尼松联合治疗的HSPN血清PTX3、IgA/C3水平与肾功能损伤的相关性进行分析。结果治疗组血清IgA、PTX3、IgA/C3、SCr水平明显高于对照组,血清IgG、IgM、eGFR、α-MG水平明显低于对照组(P<0.05)。经Pearson相关性分析,血清IgA/C3、PTX3水平均与血清SCr水平呈正相关,与血清eGFR、α-MG水平呈负相关(P<0.05)。结论经吗替麦考酚酯与泼尼松联合治疗后,HSPN患儿血清PTX3、IgA/C3水平均得到一定程度改善,且与肾功能损伤呈正相关。

Objective To explore the changes of serum pentamerin-3(PTX3)and IgA/C3 levels in patients with purpuric nephritis and their correlations with renal damage.Methods The 96 patients with purpuric nephritis treated with mycophenolate mofetil combined with prednisone treated in our hospital between May 2014 and June 2019 were selected as the treatment group while another 80 healthy physical examinees in the same period were selected as the control group.The changes of serum levels of immunoglobulin A(IgA),immunoglobulin G(IgG),immunoglobulin M(IgM),complement C3(C3)and PTX3 in the two groups were observed.The IgA/C3 value was calculated,while the difference in serum IgA/C3 levels and renal function indexes was compared between the two groups.The Pearson method was used to analyze the correlations between serum PTX3,IgA/C3 levels and renal impairment in patients with purpuric nephritis treated with mycophenolate mofetil combined with prednisone.Results Serum levels of IgA,PTX3,IgA/C3,and SCr in the treatment group were significantly higher than those of the control group,but serum IgG,IgM,eGFR,andα-MG levels were significantly lower(P<0.05).Pearson correlation analysis showed that serum IgA/C3 and PTX3 levels were positively correlated with serum SCr levels,but negatively with serum eGFR andα-MG levels(P<0.05).Conclusions After combined treatment with mycophenolate mofetil and prednisone,the serum PTX3 and IgA/C3 levels of patients with purpuric nephritis have been improved to some extent,and they are positively correlated with renal function damage.