肠内营养联合益生菌对中重度溃疡性结肠炎的疗效

Therapeutic effects of enteral nutrition combined with probiotics against moderate to severe ulcerative colitis

目的探讨肠内营养联合益生菌治疗中重度溃疡性结肠炎(ulcerative colitis,UC)的效果。方法选取2015-01至2019-12武警海警总队医院收治的85例中重度UC患者,采用随机数字表法分为对照组(42例)和联合治疗组(43例)。对照组采用益生菌治疗,联合治疗组采用益生菌联合肠内营养治疗。比较两组临床近期疗效,体重指数(body mass index,BMI)、白蛋白(albumin,ALB)、血红蛋白(hemoglobin,HGB)、总蛋白(total protein,TP)等营养状况指标,血清内毒素(serum endomycin ET)、白细胞介素4(interleukin 4,IL-4)和外周血CD4^+CD5^+等指标水平。结果联合治疗组总有效率为93.02%,显著高于对照组的76.19%,差异有统计学意义(P<0.05)。两组治疗后BMI、ALB、HGB和TP均高于治疗前,且联合治疗组明显高于对照组,差异均有统计学意义(P<0.05)。治疗后与对照组相比,联合治疗组血清ET水平更低,而血清IL-4和外周血CD4^+CD5^+水平更高,差异有统计学意义(P<0.05)。结论肠内营养联合益生菌治疗中重度UC疗效确切,可改善患者的营养状况和调节免疫功能。

Objective To investigate the therapeutic effects of enteral nutrition combined with probiotics against moderate to severe ulcerative colitis(UC).Methods A total of 85 patients with moderate to severe UC admitted to our hospital between January 2015 and December 2019 were randomly divided into the control group(42 cases)and observation group(43 cases).The control group was treated with probiotics alone while the observation group was treated with enteral nutrition combined with probiotics.The clinical efficacy of the two groups was compared based on the levels of body mass index(BMI),albumin(ALB),hemoglobin(HGB),total protein(TP)and other nutritional status indicators as well as levels of serum endomycin(ET),interleukin 4(IL-4)and peripheral blood CD4^+CD5^+.Results The total effective rate of treatment was 93.02%in the observation group,significantly higher than 76.19%in the control group,so the difference was statistically significant(P<0.05).Levels of BMI,ALB,HGB and TP were higher in both groups after treatment,especially in the observation group,with statistically significant difference(P<0.05).The serum ET level in the observation group was lower than of the control group,but the serum levels of IL-4 and CD4^+CD5^+in peripheral blood were higher,with statistically significant difference(P<0.05).Conclusions Enteral nutrition combined with probiotics is effective in the treatment of moderate to severe UC,which can improve the nutritional status of patients,regulate their immune function,and is worthy of clinical application.