流感患者外周血C反应蛋白、淋巴细胞与肺炎严重度指数的相关性分析

Correlations between peripheral blood C-reactive protein, lymphocyte and pneumonia severity indexes in patients with influenza

目的分析流感患者外周血C反应蛋白(C-reactive protein,CRP)、淋巴细胞与肺炎严重度指数(pneumonia severity index,PSI)的相关性。方法选取2019年1-4月医院收治的66例流感患者,对患者的临床资料,包括性别、年龄、身高、体重、吸烟史、饮酒史、发热时间、流感类型、血常规、PSI等进行分析。按病情情况分为重症组(30例)、轻症组(36例),对两组人口学特征、临床特征资料进行单因素分析,分析重症肺炎的影响因素。采用Spearman相关及线性回归分析C反应蛋白、淋巴细胞与PSI的相关性。结果重症组吸烟者和饮酒史者明显多于轻症组,差异均有统计学意义(P<0.05)。重症组白细胞计数、血小板计数、淋巴细胞绝对值、淋巴细胞百分率、单核细胞绝对值均明显低于轻症组,而C反应蛋白、PSI均明显高于轻症组,差异有统计学意义(P<0.05);淋巴细胞绝对值与PSI呈负相关性(r=-0.6850,P<0.001);C反应蛋白与PSI呈正相关(r=0.8523,P<0.001)。结论淋巴细胞减少、C反应蛋白增高、PSI增加是重症流感的危险因素,C反应蛋白与PSI呈正相关,淋巴细胞与PSI呈负相关。

Objective To analyze the correlations between peripheral blood C-reactive protein,lymphocytes and the pneumonia severity index in patients with influenza.Methods The 66 patients who were treated at our hospital between January 2019 and April 2019 were selected,whose clinical data such as sex,age,height,weight,smoking history,drinking history,onset time of fever,influenza type,blood routine test and pneumonia severity index was analyzed retrospectively.These cases were divided into the severe influenza group and mild influenza group based on the severity of disease.Single factor analysis was carried out on the demographic and clinical characteristics of the two groups to identify the influencing factors of severe pneumonia.Spearman correlation and linear regression were used to analyze the correlations between C-reactive protein,lymphocytes and the pneumonia severity index.Results The leukocyte count,platelet count,lymphocyte absolute value,lymphocyte percentage and monocyte absolute value in the severe influenza group were significantly lower than those in the mild influenza group,while the C-reactive protein level and pneumonia severity index were significantly higher(P<0.05).The absolute value of lymphocytes was negatively correlated with the severity index and lymphocyte percentage of pneumonia(r=-0.6850,P<0.001),while C-reactive protein was positively correlated with the severity index of pneumonia(r=0.8523,P<0.001).Conclusions The decrease of lymphocytes,increase of C-reactive protein and pneumonia severity index are risk factors for severe influenza.C-reactive protein is positively correlated with the pneumonia severity index,which is negatively correlated with lymphocytes.