马来酸桂哌齐特联合丹参川芎嗪注射液治疗脑梗死的疗效

Changes of serum IL-18, sICAM-1 and IGF-1 in patients with cerebral infarction treated with Cinepazide Maleate and Danshen Ligustrazine injection

目的通过观察治疗前后患者血清中白介素-18、可溶性细胞间黏附分子-1、胰岛素样生长因子-1的变化,探讨马来酸桂哌齐特(克林澳)联合丹参川芎嗪注射液治疗脑梗死患者的疗效。方法选择2015-09至2018-12在医院诊治的脑梗死患者135例,根据治疗方法不同分为对照组(n=65)与联合组(n=70)。对照组给予克林澳治疗,联合组在对照组治疗的基础上联合丹参川芎嗪注射液治疗,两组均治疗观察3个月,记录与检测患者血清IL-18、sICAM-1、IGF-1的变化。结果所有患者均顺利完成治疗,治疗期间无严重不良反应发生。联合组的总有效率97.1%,高于对照组的86.2%(P<0.05)。两组治疗后的MoCA评分、颅脑椎动脉与基底动脉血流速度都高于治疗前,联合组评分为(27.38±1.49)分,高于对照组的(22.88±2.69)分。两组治疗后的血清IL-18、sICAM-1、IGF-1水平均低于治疗前,联合组也低于对照组(P<0.05)。结论克林澳联合丹参川芎嗪注射液治疗脑梗死能抑制血清IL-18、sICAM-1、IGF-1的表达,改善脑血流状况,提高患者的认知功能与总体治疗效果。

Objective To investigate the therapeutic effect of Cinepazide Maleate combined with Danshen Ligustrazine injection against cerebral infarction by observing changes in serum interleukin(IL)-18,soluble intercellular adhesion molecule(sICAM)-1,and insulin-like growth(IGF)-1 in patients.Methods One hundred and thirty-five cases of patients with cerebral infarction who were treated in our hospital between September 2015 and December 2018 were selected and divided into the control group(n=65)and the combination group(n=70)according to treatment methods.The control group was treated with Cinepazide Maleate,while the combination group was additionally treated with Danshen Ligustrazine injection.Both groups were treated for 3 months,and the levels of serum IL-18,sICAM-1 and IGF-1 were detected and recorded.Results All the patients completed the treatment and no serious adverse reactions occurred during the treatment.The total effective rate of the combination group was 97.1%,which was significantly higher than that of the control group(86.2%)(P<0.05).The MoCA scores,cranial vertebral artery and basilar artery blood flow velocity in the two groups were significantly higher after treatment(P<0.05),especially in the combination group(P<0.05).The levels of serum IL-18,sICAM-1 and IGF-1 in the two groups were significantly lower after treatment(P<0.05),particularly in the combination group(P<0.05).Conclusions Cinepazide Maleate combined with Danshen Ligustrazine injection,when used in the treatment of cerebral infarction,can inhibit the expressions of serum IL-18,sICAM-1 and IGF-1,boost the cerebral blood flow and improve the cognitive function and overall therapeutic effect.