平均血小板体积与ST段抬高型心肌梗死患者血尿酸水平的相关性

Relationships between mean platelet volume and serum uric acid in patients with ST-segment elevation myocardial infarction

目的探讨平均血小板体积(mean platelet volume,MPV)与ST段抬高型心肌梗死(ST-segment elevation myocardial infarction,STEMI)患者血尿酸水平的相关性。方法选择2016-02至2018-03首都医科大学宣武医院心脏内科收治的STEMI患者322例,根据血尿酸水平分为高尿酸血症组(n=66)与正常尿酸组(n=256)。应用Pearson相关分析探究MPV与STEMI患者血尿酸水平的相关性,同时应用多元线性回归分析与Logistic回归分析探究MPV对血尿酸水平的影响。结果高尿酸血症组在年龄、体质量指数(body mass index,BMI)、白细胞(white blood cells,WBC)、MPV、肌酐(serum creatinine,SCr)、尿素氮(blood urea nitrogen,BUN)等方面均高于正常尿酸组,差异有统计学意义(P<0.05)。Pearson相关分析显示MPV与血尿酸水平呈正相关(r=0.448,P=0.000);多元线性回归分析显示BMI、红细胞(red blood cells,RBC)、MPV、SCr、BUN及三酰甘油(triglyceride,TG)均与血尿酸水平相关(P<0.05);Logistic回归分析显示MPV(OR=2.415,95%CI 1.681~3.470,P=0.000)为血尿酸水平升高的独立危险因素。结论STEMI患者的MPV与血尿酸水平呈正相关,MPV可能是STEMI患者发生高尿酸血症的危险因素之一。

Objective To investigate the relationships between the mean platelet volume(MPV)and serum uric acid(UA)levels in patients with ST-segment elevation myocardial infarction(STEMI).Methods A total of 322 patients with STEMI were enrolled in this study between February 2016 and March 2018 in Xuanwu Hospital,with an average age of(62.74±11.60)years old.These STEMI patients were divided into the hyperuricemia(HUA)group(n=66)and normal UA group(n=256)according to serum uric acid levels.Pearson analysis was used to analyze the relationships between the MPV and UA levels.Also,multivariate linear regression and Logistic regression were performed to analyze the correlations between the MPV and UA levels in STEMI patients.Results Age,body mass index(BMI),white blood cells(WBC),MPV,serum creatinine(SCr),and blood urea nitrogen(BUN)in HUA group were significantly above those in the normal UA group with a P-value less than 0.05.Pearson analysis showed that the MPV was positively correlated with UA levels(r=0.448,P=0.000).Multivariate regression analysis showed that BMI,red blood cells(RBC),MPV,SCr,BUN and triglyceride(TG)were positively correlated with UA levels(P<0.05).Logistic regression analysis showed that the MPV(OR=2.415,95%CI 1.681-3.470,P=0.000)was an independent risk factor for serum UA levels.Conclusions The MPV in STEMI patients is positively correlated with UA,and may be one of the risk factors for HUA in STEMI patients.