腹膜透析患者成纤维细胞生长因子23与股动脉内中膜厚度的相关性

Correlations between fibroblast growth factor-23 and femoral artery intima-media thickness in peritoneal dialysis patients

目的探讨腹膜透析患者成纤维细胞生长因子23(fibroblast growth factor-23,FGF-23)与股动脉内中膜厚度(intima-media thickness,IMT)的关系。方法将82例持续性非卧床腹膜透析(continuous ambulatory peritoneal dialysis,CAPD)患者根据股动脉壁最大内膜厚度不同分组,观察CAPD患者组间FGF-23与IMT的关系。结果CAPD患者中股动脉IMT增厚的检出率为45.12%,IMT增厚组患者的年龄、血磷、糖化血红蛋白、甲状旁腺激素、FGF-23水平明显高于IMT正常组,差异具有统计学意义(P<0.05),以患者IMT值作为因变量进行多元回归分析,结果显示CAPD患者的血磷、i PTH、FGF-23与患者股动脉IMT增厚独立相关(P<0.05)。结论FGF-23是慢性肾衰竭(chronic kidney disease,CKD)患者钙磷代谢紊乱、血管钙化等事件的重要生物标志物,是CAPD患者血管钙化的早期重要预警指标。

Objective To observe the correlations between fibroblast growth factor-23(FGF-23)and femoral artery intimamedia thickness(IMT)in peritoneal dialysis patients.Methods Patients on continuous ambulatory peritoneal dialysis(CAPD)were divided into different groups according the femoral artery IMT.The relationships between FGF-23 and femoral artery IMT in different CAPD groups were analyzed.Results The incidence of increased femoral artery IMT in CAPD patients was 45.12%.Age,and levels of serum phosphorous、Hb A1 c、intact parathyroid hormone(i PTH)and FGF-23 of the increased IMT group were significantly above those of the normal IMT group(P<0.05).According to multiple logistic regression analysis,the levels of serum phosphorous、i PTH and a high FGF-23 concentration were significant independent risk factors for increased IMT in CAPD patients(P<0.05).Conclusions These results suggest that a high level of FGF-23 is an important indicator of calcium-phosphorus metabolism and vascular calcification in CKD patients,and maybe an important early warning signal of vascular calcification in CAPD patients.