调阳祛邪针法治疗轻中度抑郁症的临床疗效及对IL-4、IL-10的影响

Clinical Observation on the Effect of Acupuncture Therapy for Regulating Yang and Removing Pathogenic Factors on Mild and Moderate Depression and Its Influence on IL-4 and IL-10

目的:观察调阳祛邪针法治疗轻中度抑郁症的临床疗效及对患者血清白细胞介素-4、白细胞介素水平-10的影响。方法:将轻中度抑郁症患者60例随机分为两组,针药组予调阳祛邪针法和氟西汀口服治疗,药物组单纯予氟西汀口服治疗。比较两组临床疗效,治疗前后HAMD、SAS、SDS评分及血清IL-4、IL-10水平。结果:完成3个疗程的治疗后,针药组有效率(89.3%,25/28)高于药物组(86.2%,25/29),差异无统计学意义(P>0.05)。两组治疗1个疗程、3个疗程后,HAMD、SAS、SDS评分均较前改善(P<0.05),且针药组HAMD量表评分下降更显著(P<0.05)。治疗后两组IL-4均升高(P<0.05),且针药组高于药物组(P<0.05);两组IL-10在治疗前后差异无统计学意义(P>0.05)。结论:调阳祛邪针法结合盐酸氟西汀有效改善轻中度抑郁患者的抑郁状态,疗效确切,而且能提高抗炎性细胞因子的水平。

Objective:To observe the clinical efficacy of acupuncture therapy for regulating yang and removing pathogenic factors in the treatment of mild to moderate depression and its effect on the levels of serum interleukin-4 and interleukin-10 in patients.Methods:60patients with mild to moderate depression were randomly divided into two groups.The acupuncture and drug group was treated with Yang regulating and pathogen removing acupuncture and fluoxetine orally,and the drug group was treated with fluoxetine orally.The clinical efficacy,HAMD,SAS,SDS scores before and after treatment,and serum IL-4,IL-10 levels were compared between the two groups.Re-sults:After three courses of treatment,the effective rate of the acupuncture and drug group(89.3%,25/28)was higher than that of the drug group(86.2%,25/29),with no statistically significant difference(P>0.05).After one course of treatment and three courses of treatment,HAMD,SAS and SDS scores of the two groups were improved compared with those before(P<0.05),and HAMD scale scores of the acupuncture and drug groups decreased more significantly(P<0.05).After treatment,the levels of IL-4 in both groups increased(P<0.05),and the levels of IL-4 in the acupuncture group were higher than those in the drug group(P<0.05);There was no significant difference in IL-10 between the two groups before and after treatment(P>0.05).Conclusion:Yang regulating and pathogen removing acupuncture combined with fluoxetine hydrochloride can effectively improve the depressive state of patients with mild to moderate depression,with definite effect,and can increase the level of anti-inflammatory cytokines.