参芪失笑散加味联合孕激素治疗围绝经期功能失调性子宫出血的疗效评价

Evaluation of the curative effect of Modified Shenqi Shixiao powder combined with progesterone in treating perimenopausal women with dysfunctional uterine bleeding

目的:探讨参芪失笑散治疗围绝经期功能失调性子宫出血的疗效。方法:选取2019年8月—2020年8月我院收治的96例围绝经期功能失调性子宫出血患者作为研究对象,随机分为实验组和对照组,各48例。对照组采用西药孕激素地屈孕酮片治疗,10 mg/次,每日早晚2次口服,连服10 d。实验组在对照组的基础上加用参芪失笑散加味治疗,1剂/d,3次/d,饭后1h后温服,连服5~10 d。比较两组药物治疗后的总有效率以及不良反应发生率。结果:实验组总有效率明显优于对照组,且实验组不良反应发生率(2.08%,1/48)低于对照组(18.75%,9/48);两组子宫内膜厚度评定与治疗前比较,治疗后两组的子宫内膜厚度均减少,实验组变化显著优于对照组,差异具有统计学意义(P<0.05);随访期间两组复发情况评定,随访1年,实验组复发3例(6.25%),对照组复发11例(22.92%),与对照组比较,实验组的复发率显著降低,差异具有统计学意义(P<0.05)。结论:参芪失笑散联合孕激素治疗围绝经期功能失调性子宫出血疗效确切,可改善贫血和临床各项指标,临床不良反应低,用药安全性较高。

Objective:To evaluate the therapeutic effect of Shenqi Shixiao powder on dysfunctional uterine bleeding in perimenopausal women.Methods:From August 2019 to August 2020,96 patients with perimenopausal dysfunctional uterine bleeding were randomly divided into 2 groups:experimental group(48 cases)and control group(48 cases).The control group was given the Western medicine progesterone didroxyprogesterone tablets(10 mg)twice daily morning and evening for 10 days.Experimental Group in the Control Group on the basis of adding Shenqi Shixiao powder modified treatment,a daily dose,three meals a day after an hour,followed by 5~10 days.The total effective rate and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate and the incidence of adverse reactions in the experimental group were significantly better than those in the control group,and the incidence of adverse reactions in the experimental group was 1(2.08%)lower than that in the control group 9(18.75%),after treatment,the endometrial thickness of the two groups decreased,and the change of the experimental group was significantly better than that of the control group(P<0.05),there were 11 cases(22.92%)of recurrence in the control group.The recurrence rate of the experimental group was significantly lower than that of the control group(P<0.05).Conclusion:Shenqi Shixiao powder combined with progestin is effective in the treatment of perimenopausal women,can improve anemia and clinical indicators,its clinical adverse reaction is low,the safety of medication is higher.