利用JSRV构建啮齿动物LPA模型研究进展

Advances in the construction of rodent LPA models using JSRV

针对绵羊肺腺瘤病毒(Jaagsiekte sheep retrovirus,JSRV)构建啮齿动物鳞屑样生长型肺腺癌(Lepidic predominant adenocarcinomas,LPA)模型的问题,采用文献检索的方式,以"JSRV"、"adenocarcinomas"、"mouse model"为检索词,对利用JSRV构建啮齿动物LPA模型的相关文献进行归纳整理。结果表明:该模型主要构建方法为干扰质粒介导体内细胞转化或培育转基因动物;该模型中被激活的信号通路为肿瘤经典信号通路PI3K/Akt及MAPK信号通路;该模型具备相对完善的生物信息学数据支撑,是深入探讨LPA分子水平致病机制的良好模型。在LPA的致病机制以及LPA不同发病阶段靶向药物筛选方面有待进一步研究。

In order to address the question of construct the rodent lepidic predominant adenocarcinomas(LPA) model,literatures related to LPA using Jaagsiekte sheep retrovirus(JSRV) were searched by using "JSRV","adenococinomas" and "mouse model" as keywords.The related literatures were reviewed and summarized.The results showed that:Numerous studies demonstrated that JSRV-mediated rodent cell transformation mainly depended on non-receptor-dependent mechanisms,through PI3K/Akt and Ras/MEK/MAPK signaling pathways.The main construction method was transfecting plasmid into cells or to breed transgenic animals.The rodent LPA model constructed using JSRV based on complete bioinformatics data was optimal model for further study of the pathogenic mechanism of LPA molecules.However,the pathogenesis of LPA and the targeted drug for different stages of LPA need further studies.