高渗盐水联合布地奈德雾化吸入对肺部感染新生儿炎症因子及Th1/Th2的影响

Effect of Hypertonic Saline Combined with Dudesonide Inhalation on Inflammatory Factors and Th1/Th2 in Neonates with Pulmonary Infection

目的探讨高渗盐水联合布地奈德雾化吸入对肺部感染新生儿炎症因子及Th1/Th2的影响。方法选择我院2017年8月至2019年4月收治的86例肺部感染新生儿,随机分为对照组43例,观察组43例。对照组采用常规治疗,在此基础上,观察组采用高渗盐水联合布地奈德雾化吸入治疗,比较两组临床疗效、炎症因子、Th1/Th2。结果较对照组相比,治疗后,观察组总有效率、IL-10水平较高,TNF-α、Th1/Th2水平较低,差异有统计学意义(P<0.05);两组不良反应发生率相比,差异无统计学意义(P>0.05)。结论高渗盐水联合布地奈德雾化吸入可降低肺部感染新生儿机体炎症因子及Th1/Th2,提升临床疗效,且用药安全性高。

Objective To investigate the effect of hypertonic saline combined with budesonide inhalation on inflammatory factors and Th1/Th2 in neonates with pulmonary infection.Methods 86 neonates with pulmonary infection admitted in our hospital from August 2017 to April 2019 were randomly divided into control group(43 cases)and observation group(43 cases).The control group was treated with conventional therapy.On this basis,the observation group was treated with hypertonic saline combined with budesonide atomization inhalation.The clinical efficacy,inflammatory factors and Th1/Th2 of the two groups were compared.Results Compared with the control group,the total effective rate and the level of IL-10 in the observation group were higher,the level of TNF-αand Th1/Th2 were lower,the difference was statistically significant(P<0.05);there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Hypertonic saline combined with budesonide atomization inhalation can reduce the inflammatory factors and Th1/Th2 in neonates with pulmonary infection,improve the clinical efficacy,and the drug safety is high.