(1R,2S)-1-苯基-2-(1-吡咯烷基)-1-丙醇合成研究
Study on the Synthesis of (1R, 2S)-1-Phenyl-2-(1-Pyrrolidinyl)-1-Propanol
摘要
溴代苯丙酮与四氢吡咯碱性条件反应得DL-1-苯基-2-(1吡咯烷基)-1-丙酮,经拆分、还原、精制等步骤,合成化合物(1R,2S)-1-苯基-2-(1-吡咯烷基)-1-丙醇。精制得到(1R,2S)-1-苯基-2-(1-吡咯烷基)-1-丙醇,总收率为46.2%,含量为99.98%。
出处
《内蒙古石油化工》
CAS
2021年第3期75-76,108,共3页
Inner Mongolia Petrochemical Industry
参考文献2
-
1叶海伟,俞传明,钟为慧,苏为科.(1R,2R)-2-((R)-3-(苄氧基)吡咯烷基)环己醇的合成研究[J].高校化学工程学报,2014,28(3):606-611. 被引量：3
-
2尹安琴,薛思佳,方治坤,陈龙,胥杨.(S)-(＋)-N-取代吡咯烷甲醇衍生物的合成及晶体结构[J].有机化学,2010,30(4):601-605. 被引量：1
二级参考文献19
-
1Zimetbaum P. Amiodarone for atrial fibrillation [J]. N Engl J Med, 2007, 356: 935-941.
-
2Friederich P, Pfizenmayer H. The novel Kv1.5 channel blocker vernakaJant for successful treatment of new-onset atrial fibrillation in a critically ill abdominal surgical patient [J]. Br J Anaesth. 2011, 107(4): 644-645.
-
3Bronis K, Metaxa S, Koulouris S, et al. Vernakalant: review of a novel atrial selective antiarrhythmic agent and its place in current treatment of atrial fibrillation [J]. Hospital Chronicles, 2012, 7(3): 171-181.
-
4Li J J, Johnson D S. Modern drug synthesis [M]. Canada: A John Wiley & Sons, Inc., Press, 2010: 159-173.
-
5Roy D, Pratt C M, Torp-Pedersen C. et al. Vernakalant hydrochloride for rapid conversion of atrial fibrillation : A Phase 3, randomized, placebo-controlled trial [J]. Circulation, 2008, 117: 1518-1525.
-
6Kowey P R, Dorian P, Brent Mitchell L, et al. Vernakalant hydrochloride for the rapid conversion of atrial fibrillation after cardiac surgery: A randomized, double-blind, placebo-controlled trial [J]. Circ Arrhythmia Elec. 2009,2: 652-659.
-
7Dobrev D, Hamad B, Kirkpatrick P. Vernakalant [J]. Nat Rev Drug Discov, 2010, 9: 915-916.
-
8Revill P, Serradell N, Bol6s J, et al. Vernakalant hydrochloride [J]. Drugs of the Future, 2007, 32(3): 234-244.
-
9Marinelli A, Ciccarelli I, Capucci A. Vernakalant hydrochloride in the treatment of atrial fibrillation: a review of the latest clinical evidence [J]. Clin Invest, 2011, 1(4): 579-588.
-
10Plouvier B M C, Chou D T, Jung G, et al. Synthetic process for aminocyclohexyl ether compounds. US, 2006 088 525 [P]. 2006-08-24.
