肥厚型心肌病患者晕厥相关因素探讨

Related factors of syncope in patients with hypertrophic cardiomyopathy

目的:探讨肥厚型心肌病(HCM)患者晕厥发生的相关因素。方法:回顾性收集78例HCM患者的临床资料,根据有无发生晕厥,分为晕厥组(22例)和无晕厥组(56例),统计分析2组相关指标。结果:HCM患者晕厥组年龄较无晕厥组偏高[(59.6±10.3)岁vs(50.2±14.5)岁,P=0.007];N末端脑钠肽前体水平较无晕厥组偏低[(1031.4±1959.3)ng/L vs(3063.8±3847.8)ng/L,P=0.02];心率较无晕厥组偏低[(64.9±13.5)次/min vs(76.6±23.2)次/min,P=0.01];房性早搏数目较无晕厥组高[(257.8±392.1)次/d vs(96.4±325.5)次/d,P=0.02];房性心动过速发生率较无晕厥组高(45.5%vs 21.4%,P=0.03)。2组影像学指标比较,差异无统计学意义。Logistic回归分析显示,年龄、心率、房性心动过速发生率是晕厥的相关危险因素。结论:年龄、心率、房性心动过速发生率是HCM患者发生晕厥的相关危险因素。

Objective:To investigate the related factors of syncope in patients with hypertrophic cardiomyopathy(HCM).Methods:The clinical data of 78 patients with HCM were retrospectively collected,and the patients were divided into syncope group(22 cases)and non-syncope group(56 cases).The related indicators were statistically analyzed in two groups.Results:The age in syncope group was significantly older than that in non-syncope group[(59.6±10.3)years vs(50.2±14.5)years,P=0.007].The level of N-terminal pro-brain natriuretic peptide was significantly lower in syncope group than that in the non-syncope group[(1031.4±1959.3)ng/L vs(3063.8±3847.8)ng/L,P=0.02].Heart rate was significantly lower in syncope group than that in non-syncope group[(64.9±13.5)beats/min vs(76.6±23.2)beats/min,P=0.01].The number of premature atrial beats was significantly greater in syncope group than in non-syncope[(257.8±392.1)beats vs(96.4±325.5)beats,P=0.02].The number of patients with atrial tachycardia was significantly greater in syncope group than that in non-syncope group(45.5%vs 21.4%,P=0.03).There was no significant difference in imaging indexes between the two groups.Logistic regression analysis showed that age,heart rate,and number of atrial tachycardia cases were related risk factors for syncope.Conclusion:Age,heart rate,and number of atrial tachycardia cases were the related risk factors for syncope in HCM patients.