2型糖尿病患者血清25-羟维生素D3水平与颈动脉硬化的相关性分析

Correlation between serum 25-hydroxyvitamin D3 and carotid atherosclerosis in patients with type 2 diabetes mellitus

目的:探讨2型糖尿病(type 2 diabetes mellitus,T2DM)患者血清25-羟维生素D3[25(OH)D3]水平与颈动脉硬化(carotid atherosclerosis,CAS)的相关性。方法:选取2018年在华东疗养院体检的345例2型糖尿病患者为研究对象,根据颈动脉彩超结果分为颈动脉斑块(T2DM-CAS)组和无斑块(T2DM-NCAS)组,同时选取无糖尿病无颈动脉硬化的人群131例作为对照组。采集一般资料和临床信息,测定血清25(OH)D3及糖脂相关生化指标,分析25(OH)D3及其他生化指标与CAS的相关性。结果:血清25(OH)D3水平在糖尿病患者和对照组中并没有显著差异。经性别分层分析后发现,对于男性T2DM患者,T2DM-CAS组血清25(OH)D3明显低于T2DM-NCAS组,经Logistic回归分析发现25(OH)D3是CAS的独立影响因素。但对于女性T2DM患者,CAS仅与年龄和脉压有关。经年龄分层分析发现血清25(OH)D3水平与年龄无明显相关性。结论:血清25(OH)D3水平在T2DM患者和对照人群中并没有显著差异。对于男性患者,血清25(OH)D3水平降低是T2DM伴CAS的独立危险因素。

Objective:This study aims to investigate the correlation between serum 25-hydroxyvitamin D3[25(OH)D3]level and carotid atherosclerosis(CAS)in patients with type 2 diabetes mellitus(T2DM).Methods:The clinical information of 345 patients with T2DM were collected.According to carotid artery color Doppler ultrasound results,the patients were divided into two groups:T2DM with or without atherosclerosis(T2DM-CAS,T2DM-NCAS).There were 131 normal samples without T2DM nor CAS enrolled as control group.The serum 25(OH)D3 and other biochemical parameters were measured.Results:There was no significant difference in the level of serum 25(OH)D3 between T2DM group and control group.In the male T2DM patients,the serum 25(OH)D3 was significantly lower in T2DM-CAS than in T2DM-NCAS and acted as an independent impact factor for CAS by binary logistic regression analysis.However,for female T2DM patients,CAS was only related to age and pulse pressure.There was no correlation between the level of serum 25(OH)D3 and age in T2DM patients.Conclusion:There was no significant difference in the serum 25(OH)D3 level between the T2DM patients and control.For the male T2DM patients,the serum 25(OH)D3 reduction is a risk factor for CAS.