环境丰富化:重塑大脑的交响乐

Environmental enrichment: a symphony facilitating brain remodeling

哺乳类大脑是高度可塑的。环境丰富化作为非侵入式手段已被广泛用于增强大脑可塑性。EE能够显著改善各种脑功能,包括脑发育、脑衰老、脑损伤修复和大脑对应激的反应等,从而有益于脑发育疾病、神经退行性疾病、脑卒中和脑创伤、情绪障碍疾病及物质依赖等疾病的治疗。然而,EE的作用还停留在实验室阶段,临床转化仍较困难。发现EE产生效应的关键分子底物是促进其临床转化的重要策略。

The mammalian brain is highly plastic.Environmental enrichment(EE)has been widely used as a noninvasive means to enhance brain plasticity.EE extensively improves brain functions,including development,aging,recovery from damages and response to stress stimulations,thereby benefits the treatment of neurodevelopmental disorders,neurodegenerative diseases,stroke and traumatic brain injury,affective disorders and substance addiction.However,EE has largely remained a laboratory phenomenon with little translation to the clinical setting.A critical strategy for the clinical translation of EE is to identify key molecular substrate of effects of EE on brain plasticity.