炎性因子在消化道肿瘤术后ERAS管理中吻合口漏的预测作用及研究进展

The role and research progress of inflammatory factors in prediction of anastomotic leakage after gastrointestinal tumor surgery within an enhanced recovery after surgery (ERAS) program

近年来随着加速康复外科(enhanced recovery after surgery,ERAS)不断推广与完善,快速康复成为消化道肿瘤围手术期管理的重要内容。通过围手术期ERAS管理,患者平均住院时间明显缩短,但仍存在一些并发症(如吻合口漏等)难以早期发现,从而增加了患者再入院的风险。大量文献提出,一些炎性因子与术后吻合口漏有显著相关性,且对其发生有重要预测价值,但其在ERAS风险管控中的预测价值尚无报道。文章就炎性因子在消化道肿瘤术后ERAS管理中预测吻合口漏的研究进展进行综述,以期寻找较敏感的预测指标,指导患者安全出院。

In recent years,with the continuous promotion and improvement of enhanced recovery after surgery(ERAS),rapid recovery has become an important part of perioperative management of gastrointestinal tumors.Under the influence of ERAS,the average hospital stay of patients has been significantly shortened,but some complications(such as anastomotic leakage)are difficult to be detected early,thus increasing the risk of hospital readmission.A large number of literatures proposed that some inflammatory factors were significantly correlated with postoperative anastomotic leakage and had important predictive value in its occurrence,but its predictive value in risk management and control in ERAS has not been reported.In this paper,research progress of inflammatory factors in predicting anastomotic leakage in postoperative ERAS management of digestive tract tumors was reviewed,in order to search for more sensitive predictors to guide patients discharged safely.