进展期胃癌组织中FOXP1和Ki67的表达及对患者预后的影响

The expressions of FOXP1 and Ki67 in advanced gastric cancer and the effects on the prognosis of patients

目的:分析进展期胃癌中叉头框P1(forkhead box P1,FOXP1)的表达与增殖因子Ki67的关系,探讨FOXP1联合Ki67与临床各参数之间的相关性及对预后的影响。方法:采用石蜡切片免疫组化SP法分析胃癌及癌旁组织中FOXP1和Ki67表达,对FOXP1和Ki67表达的相关性进行Pearson相关分析,采用单因素和多因素回归分析两者对患者预后的影响。结果:FOXP1在癌组织中低表达,FOXP1和Ki67蛋白的表达在胃癌组织中呈负相关。Ki67高表达和FOXP1低表达是进展期胃癌患者无复发生存期的影响因素。结论:Ki67和FOXP1在进展期胃癌组织中的表达呈负相关,二者共同影响胃癌患者预后。

Objective:To analyze the correlation between the expression of forkhead box P1(FOXP1)and proliferative factor Ki67 protein,and investigate the effects on prognosis of advanced gastric carcinoma patients.Methods:Paraffin-embedded sections immunohistochemical SP method was used to detect the expression of FOXP1 and Ki67 in gastric sdenocarcinoma and paracancerous tissue.Pearson rank correlation analysis was used to analyze the relationship,and regression analysis was performed to estimate the effects of FOXP1 and Ki67 expression on the recurrence-free survival(RFS).Results:The expressions of FOXP1 were lower in the gastric cancer tissues than in the corresponding adjacentnon-tumor tissues.There was negative correlation between the expression of FOXP1 and Ki67 in gastric cancer tissue.The results showed that the loss of FOXP1 expression and the higher Ki67 expression were influential factors of efficacy in the RFS.Conclusion:The expression of FOXP1 negatively correlates with the expression of Ki67 in gastric carcinoma.A loss of FOXP1 expression and a higher Ki67 expression affect the prognosis of gastric carcinoma patients together.