可调压腰大池-腹腔分流术治疗交通性脑积水疗效及对NIHSS评分、血清NSE、s100B水平的影响

Therapeutic effect of adjustable pressure waist pool-peritoneal shunt on the treatment of communicating hydrocephalus and Its effect on nIHSS score,serum NSE and S100B levels

目的研究可调压腰大池-腹腔分流对交通性脑积水患者的疗效及对NIHSS、血清NSE、s100B水平的影响。方法选取2010年2月~2017年10月我院收治的交通性脑积水患者92例。将其以随机数字表法均分成研究组和对照组,对照组采用侧脑室腹腔分流术治疗,研究组则采用可调压腰大池-腹腔分流术治疗。分别比较两组临床疗效,治疗前后美国国立卫生研究院卒中量表(NIHSS)、血清神经元特异性烯醇化酶(NSE)、中枢神经特异性蛋白(s100B)水平以及术后并发症发生情况。结果研究组优良率为97.83%,明显高于对照组的84.78%,差异有统计学意义(P<0.05)。两组治疗后NIHSS评分均明显低于术前,且治疗后研究组明显低于对照组,差异有统计学意义(P<0.05)。两组治疗后血清NSE、s100B水平均显著降低,且治疗后研究组均显著低于对照组,差异有统计学意义(P<0.05)。研究组并发症发生率为10.87%,明显低于对照组的28.26%,差异有统计学意义(P<0.05)。结论可调压腰大池-腹腔分流术应用于交通性脑积水患者中具有显著疗效,且有效改善NIHSS,降低脑组织的缺血缺氧损伤以及并发症发生风险,安全性良好。

Objective To study the therapeutic effect of adjustable pressure waist pool-peritoneal shunt on the treatment of communicating hydrocephalus and its effect on NIHSS score,serum NSE and s100 B levels.Methods Ninety-two patients with communicating hydrocephalus admitted to our hospital from February 2010 to October 2017 were selected.They were divided into study group and control group by random number table method.The control group was treated with lateral ventriculo-peritoneal shunt.The study group was treated with adjustable pressure waist pool-peritoneal shunt.The clinical efficacy of the two groups was compared.The national institutes of health stroke scale(NIHSS) before and after treatment,serum neuron-specific enolase(NSE),central nervous system-specific protein(s100 B) levels,and postoperative complications occurred situation were compared.Results The excellent and good rate of the study group was 97.83%,which was significantly higher than that of the control group(84.78%).The difference was statistically significant(P<0.05).The NIHSS scores of the two groups were significantly lower than those before the operation,and the study group was significantly lower than the control group after treatment(P<0.05).Serum NSE and s100 B levels were significantly lower after treatment in both groups,and the study group was significantly lower than the control group after treatment,the difference was statistically significant(P<0.05).The complication rate of the study group was 10.87%,which was significantly lower than 28.26% of the control group.The difference was statistically significant(P<0.05).Conclusion Adjustable compression waist large pool-peritoneal shunt has significant curative effect in the treatment of patients with communicating hydrocephalus,and it can effectively improve NIHSS,reduce the risk of ischemia and hypoxia injury of brain tissue and complications occurrence,and has good safety.