老年性帕金森病轻度认知功能障碍与基底核团铁代谢的相关性研究

The Analysis on the correlation between the iron metabolism of the basal ganglia and mild cognitive impairment in senile Parkinson’s disease

目的探讨老年性帕金森病患者轻度认知功能障碍与基底核团铁代谢的相关性。方法选取我院于2016年5月~2019年5月治疗的老年性帕金森病患者46例,根据认知功能评分,25例正常为对照组,21例轻度认知功能障碍为观察组,所有患者均采用磁敏感成像分析脑黑质、红核、丘脑、壳核、尾状核头部、苍白球及额叶白质的相位值,分析两组之间差异。结果两组患者受教育年限存在显著差异,观察组教育年限显著低于对照组(P<0.05),磁敏感加权成像显示观察组苍白球和尾状核头部的相位值显著高于对照组(P<0.05)。结论磁敏感加权成像可以定量分析帕金森病患者的脑铁代谢情况,帕金森病合并有轻度认知功能障碍患者,较认知功能正常的患者存在苍白球、尾状核头部的铁离子浓度增高。

Objective To explore the correlation between the iron metabolism of the basal ganglia and mild cognitive impairment in senile Parkinson’s disease.Methods Admitted into 46 patients with senile Parkinson’s disease in our hospital from May 2016 to May 2019,and then according to the cognitive function score,divided them into control group of 25 cases with the normal score,and observation group of 21 cases with mild cognitive impairment(MCI),all patients undertook susceptibility weighted imaging(SWI) scanning to calculate the phase values of brain substantia nigra,red nucleus,the thalamus,putamen,the head of caudate nucleus,globus pallidus and the frontal white matter,then analyzed the difference between two groups.Results There was a significant difference in the number of years of education between the two groups.The number of years of education in the observation group was significantly lower than that in the control group(P<0.05).SWI showed that the phase values of the globus pallidum and the head of the caudate nucleus in the observation group were significantly higher than those in the control group(P<0.05).Conclusion SWI can be used to quantitatively study the iron metabolism in the brain of patients with Parkinson’s disease.PD with MCI have higher iron concentrations in the globus pallidus and the head of the caudata nucleus than those with normal cognitive function.