氟喹诺酮类药物的禁忌证不良反应及临床合理用药对策

目的探究氟喹诺酮类药物的禁忌症及不良反应,并总结临床合理用药对策。方法选择102例我中心发生及收治氟喹诺酮类药物所致不良反应的患者予以回顾性分析,纳入时间为2016年8月至2017年8月,总结氟喹诺酮类药物所致不良反应患者年龄分布、药物类别及临床表现。结果102例氟喹诺酮类药物所致不良反应的患者中,超过60周岁及51至60周岁年龄段发生氟喹诺酮类药物不良反应比例较高,其发生率分别为37.25%、16.67%。静脉注射所致不良反应85例,占比83.33%;口服药物所致不良反应17例,占比16.67%。其中左氧氟沙星与环丙沙星发生不良反应比例较高,分别为40.20%(静脉注射)、7.84%(口服);20.59%(静脉输注)、4.90%(口服)。皮肤及消化系统功能影响较大,分别占比28.43%、22.55%。结论氟喹诺酮类药物所致不良反应临床发生率较高,应通过临床合理用药方式降低不良反应发生比例。

Objective:To investigate the contraindications and adverse reactions of fluoroquinolones and to summarize the clinical countermeasures.Methods:102 patients with adverse reactions caused by fluoroquinolones were selected and treated in our center for retrospective analysis.The time was from August 2016 to August 2017.The age distribution,drug type and clinical manifestation of patients with adverse reactions caused by fluoroquinolones were summarized.Conclusion:The clinical incidence of adverse reactions caused by fluoroquinolones is high,and the proportion of adverse reactions should be reduced by rational clinical use.