摘要
Fluorescent silk is fundamentally important for the development of future tissue engineering scaffolds.Despite great progress in the preparation of a variety of colored silks,fluorescent silk with enhanced mechanical properties has yet to be explored.In this study,we report on the fabrication of intrinsically super-strong fluorescent silk by feeding Bombyx mori silkworm carbon nanodots(CNDs).The CNDs were incorporated into silk fibroin,hindering the conformation transformation,confining crystallization,and inducing orientation of mesophase.The resultant silk exhibited super-strong mechanical properties with breaking strength of 521.9±82.7 MPa and breaking elongation of 19.2±4.3%,improvements of 55.1%and 53.6%,respectively,in comparison with regular silk.The CNDs-reinforced silk displayed intrinsic blue fluorescence when exposed to 405 nm laser and exhibited no cytotoxic effect on cells,suggesting that multi-functional silks would be potentially useful in bioimaging and other applications.
Fluorescent silk is fundamentally important for the development of future tissue engineering sca olds. Despite great progress in the preparation of a variety of colored silks, fluorescent silk with enhanced mechanical properties has yet to be explored. In this study, we report on the fabrication of intrinsically super?strong fluorescent silk by feeding Bombyx mori silkworm carbon nanodots(CNDs). The CNDs were incorporated into silk fibroin, hindering the conformation transformation, confining crystallization, and inducing orientation of mesophase. The resultant silk exhibited super?strong mechanical properties with breaking strength of 521.9 ± 82.7 MPa and breaking elongation of 19.2 ± 4.3%, improvements of 55.1% and 53.6%, respectively, in comparison with regular silk. The CNDs?reinforced silk displayed intrinsic blue fluorescence when exposed to 405 nm laser and exhibited no cytotoxic e ect on cells, suggesting that multi?functional silks would be potentially useful in bioimaging and other applications.
基金
sponsored by the National Key Research and Development Program of China(2016YFA0201700,2016YFA0201702)
the Fundamental Research Funds for the Central Universities(2232019A3-06,2232019D3-02)
the National Key Research and Development Program of China(2018YFC1105800)
the National Natural Science Foundation of China(21674018,51903045)
the Shanghai Belt and Road Joint Laboratory of Advanced Fiber and Low-Dimension Materials(18520750400).