冠状动脉微循环障碍在冠状动脉粥样硬化性心脏病中的研究进展

Research progress in the role of coronary microcirculation dysfunction in coronary atherosclerotic heart disease

冠状动脉粥样硬化性心脏病(CHD)的发病率越来越高,亦呈年轻化趋势,已成为严重影响人类健康的心血管疾病之一。随着医学研究进展,CHD发病机制的研究虽不断深入,但仍不明确。尽管冠状动脉造影(CAG)是诊断CHD的金标准,但大量临床及相关研究表明,CAG正常而仍存在胸痛的患者数量并不罕见,怀疑此现象由冠状动脉微循环障碍(CMD)引起,CMD在CHD发病中具有重要意义。本研究主要通过CMD在CHD中的发病机制、研究进展、评估、治疗及展望作一综述。

The morbidity of coronary atherosclerotic heart disease(CHD)has been in an increasing trend,and also moving more to younger people.It has become one of the cardiovascular diseases seriously affecting human health.With the development of medical research,research into the pathogenesis of CHD has been advanced,but everything is not yet confirmed in this respect.Although coronary arteriongraphy(CAG)is the gold standard for diagnosing CHD,a large number of clinical and related studies have shown that patients with normal CAG and chest pain are not uncommon nowadays.This phenomenon is suspected to be related to coronary microcirculation dysfunction(CMD).It is clear that CMD plays an important role in the pathogenesis of CHD.This article reviewed the pathogenesis,research progress,assessment,treatment and prospects of CMD in CHD.