摘要
目的分析西安市农村居民高血压与血脂水平的相关性。方法选取西安市户县一个自然村40岁以上的常住村民1560人作为研究对象,排除正在服用降压药物及调脂药物者。收集翔实的基线资料,测定肱动脉随机坐位血压,采集空腹静脉血测定甘油三酯(TG)、胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)水平。单因素及多因素分析评价高血压与血脂水平的相关性。结果研究对象中符合高血压病诊断标准578人(37.1%),符合血脂异常诊断标准508人(32.6%)。单因素分析显示,血脂异常组高血压病患病率、收缩压水平、舒张压水平均显著高于血脂正常组(P<0.05)。以高血压病为因变量做Logistic回归显示,高血压病与TG和高TG血症呈正相关关系(OR=1.224,95%CI:[1.065,1.454],P=0.006;OR=1.583,95%CI:[1.177,2.130],P=0.002)。以收缩压或舒张压为因变量做线性回归校正其他混杂因素后显示:收缩压与TG、高TG血症呈正相关关系(β=2.038,P<0.001;β=4.085,P<0.001),舒张压与TG、高TG血症呈正相关关系(β=1.381,P<0.001;β=2.715,P<0.001)。结论西安市农村地区40岁以上人群高血压与血脂水平存在相关关系,尤其与TG存在显著正相关关系,在高血压病的防治过程中应注意对血脂,尤其是对TG的监测和控制。
Objective To explore the relationship between hypertension and lipid levels in population from a rural area of Xi’an.Methods A total of 1560 subjects(aged above 40)from a village in Hu County of Xi’an were enrolled.Baseline data were collected and blood pressure measured in a seated position.Fasting blood lipids(serum cholesterol,serum triglycerides,serum low-density lipoprotein and serum high-density lipoprotein)were tested.The relationship between blood pressure and lipid levels was analyzed using a univariateanalysis,multivariate Logistic regression analysis and multiple linear regression analysis.Results In those subjects,578(37.1%)were diagnosed as having hypertension,508(32.6%)as having dyslipidemia.The univariate analysis showed that the prevalence of hypertension,systolic blood pressure and diastolic blood pressure in the dyslipidemia group was significantly higher than those in the normal lipid group(P<0.05).The multivariate Logistic regression analysis showed that hypertension was in a positive correlation with triglycerides(TG)and hypertriglyceridemia(OR=1.224,95%CI:[1.065,1.454],P=0.006;OR=0.583,95%CI:[1.177,2.130],P=0.002).The multiple linear regression analysis showed that systolic blood pressure was in a positive correlation with TG and hypertriglyceridemia(β=2.038,P<0.001;β=4.085,P<0.001),and diastolic blood pressure was in a positive correlation with TG and hypertriglyceridemia(β=1.381,P<0.001;β=2.715,P<0.001).Conclusion There was a positive correlation between hypertension and blood lipid levels,especially with triglycerides in population over 40 years old in a rural area of Xi’an.In the process of hypertension prevention we should pay more attention to the control of blood lipids,especially triglycerides.
作者
王瑾
张彬艳
商苏杭
李珮
邓美英
江毓
陈晨
屈秋民
Wang Jin;Zhang Bin-yan;Shang Su-hang;Li Pei;Deng Mei-ying;Jiang Yu;Chen Chen;Qu Qiu-min(Department of Neurology,The First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China;School of Public Health,Health Science Center,Xi'an Jiaotong University,Xi'an 710061,China)
出处
《兰州大学学报(医学版)》
CAS
2018年第6期14-19,共6页
Journal of Lanzhou University(Medical Sciences)
基金
国家自然科学基金项目(81771168)
陕西省重点研究发展计划项目(2017SF-260).
关键词
高血压
血脂异常
甘油三酯
农村居民
hypertension
dyslipidemia
triglyceride
population from a rural area