西安市农村居民高血压与血脂水平的相关性研究

Relationship between hypertension and lipid level in population from a rural area of Xi'an

目的分析西安市农村居民高血压与血脂水平的相关性。方法选取西安市户县一个自然村40岁以上的常住村民1560人作为研究对象,排除正在服用降压药物及调脂药物者。收集翔实的基线资料,测定肱动脉随机坐位血压,采集空腹静脉血测定甘油三酯(TG)、胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)水平。单因素及多因素分析评价高血压与血脂水平的相关性。结果研究对象中符合高血压病诊断标准578人(37.1%),符合血脂异常诊断标准508人(32.6%)。单因素分析显示,血脂异常组高血压病患病率、收缩压水平、舒张压水平均显著高于血脂正常组(P<0.05)。以高血压病为因变量做Logistic回归显示,高血压病与TG和高TG血症呈正相关关系(OR=1.224,95%CI:[1.065,1.454],P=0.006;OR=1.583,95%CI:[1.177,2.130],P=0.002)。以收缩压或舒张压为因变量做线性回归校正其他混杂因素后显示:收缩压与TG、高TG血症呈正相关关系(β=2.038,P<0.001;β=4.085,P<0.001),舒张压与TG、高TG血症呈正相关关系(β=1.381,P<0.001;β=2.715,P<0.001)。结论西安市农村地区40岁以上人群高血压与血脂水平存在相关关系,尤其与TG存在显著正相关关系,在高血压病的防治过程中应注意对血脂,尤其是对TG的监测和控制。

Objective To explore the relationship between hypertension and lipid levels in population from a rural area of Xi’an.Methods A total of 1560 subjects(aged above 40)from a village in Hu County of Xi’an were enrolled.Baseline data were collected and blood pressure measured in a seated position.Fasting blood lipids(serum cholesterol,serum triglycerides,serum low-density lipoprotein and serum high-density lipoprotein)were tested.The relationship between blood pressure and lipid levels was analyzed using a univariateanalysis,multivariate Logistic regression analysis and multiple linear regression analysis.Results In those subjects,578(37.1%)were diagnosed as having hypertension,508(32.6%)as having dyslipidemia.The univariate analysis showed that the prevalence of hypertension,systolic blood pressure and diastolic blood pressure in the dyslipidemia group was significantly higher than those in the normal lipid group(P<0.05).The multivariate Logistic regression analysis showed that hypertension was in a positive correlation with triglycerides(TG)and hypertriglyceridemia(OR=1.224,95%CI:[1.065,1.454],P=0.006;OR=0.583,95%CI:[1.177,2.130],P=0.002).The multiple linear regression analysis showed that systolic blood pressure was in a positive correlation with TG and hypertriglyceridemia(β=2.038,P<0.001;β=4.085,P<0.001),and diastolic blood pressure was in a positive correlation with TG and hypertriglyceridemia(β=1.381,P<0.001;β=2.715,P<0.001).Conclusion There was a positive correlation between hypertension and blood lipid levels,especially with triglycerides in population over 40 years old in a rural area of Xi’an.In the process of hypertension prevention we should pay more attention to the control of blood lipids,especially triglycerides.