试论“伏瘀伤骨、肾虚瘀重、络虚络瘀”为绝经后骨质疏松症(PMOP)中医发病病机通路

Discussion on the TCM Pathogenesis Pathways of Postmenopausal Osteoporosis“Latent Stasis Injures Bone,kidney Deficiency Leads to Aggravation of Stasis,and Collaterals Get Deficiency and Stasis”

绝经后骨质疏松症(PMOP)是一种涉及骨科、妇科、内分泌等多学科交叉性的疾病,随着科学技术的发展及医学科研的进步,PMOP病机的复杂性、治疗的棘手性导致其研究发展的方向必然趋向多中心、多学科协作,最便捷的方式即为西医学与中医学优势互补,二者病机通路的贯通是首要关键。然而,中医病机学基础与西医学理论基础不同,中医学对PMOP的认识无法从西医学角度、微观医学角度及在实验室中被证实。文章旨在探讨PMOP重要西医学病理机制与中医理论的关系,构建一套较完善的PMOP"中医发病的病机通路",即PMOP的中医病机模型为"伏瘀伤骨、肾虚瘀重、络虚络瘀",在制定该病治则时,除却应用经典的补肾、壮骨药物,更应该佐以活血化瘀及有通络功能的药物加强对该病病理因素的祛除。

Postmenopausal osteoporosis is a kind of interdisciplinary disease which involved in orthopedics,gynaecology and endocrine.With the development of scientific technology and the progress of medical research,the development of its research direction tends to be more centers and multidisciplinary collaboration under the complexity of its pathogenesis and treatment,and the most convenient form is the advantages of TCM and Western medicine complement each other.As a result,the breakthrough of its pathogenesis pathways of TCM and Western is primary.However,the basis of TCM pathogenesis is different from the theoretical basis of Western medicine,so the understanding of PMOP in TCM can not be confirmed from the perspective of Western medicine and laboratory.The purpose of this paper is to explore the relationship between Western medicine pathological mechanism and TCM theory of PMOP,and to build a“TCM pathogenesis of the disease pathways”of PMOP,that the TCM pathogenesis model of PMOP is“latent stasis injures bone,kidney deficiency leads to aggravation of stasis,and collaterals get deficiency and stasis”.So when making the disease therapeutic principle,what we need is the herbs that could activate blood circulation and remove blood stasis besides the kidney-tonifying and bone-strengthening.