TRPV1参与心肌缺血/再灌注损伤保护作用机制研究进展

Research Progress of Protective Effect of TRPV1 on Myocardial Ischemia/ Reperfusion Injury

心肌缺血/再灌注损伤(MIRI)是心肌组织在较长时间缺血后恢复血液灌流,反而出现比再灌注前更明显、更严重的损伤和功能障碍。最近研究发现,TRPV1是心肌损伤后胸痛检测途径中的重要参与者,且参与心肌缺血/再灌注,可能对MIRI损伤发挥一定的保护作用,但其作用机制不尽相同。该文主要阐述了TRPV1通过改善对心功能、病理损伤和心肌细胞损伤而发挥对MIRI的保护作用,以及减少自由基的的释放、抑制心肌细胞凋亡、降低炎症因子的释放、改善线粒体功能和调控相关因子和信号传导通路等机制研究,对TRPV1参与MIRI损伤保护作用进行综述,从而发现及研究治疗心肌缺血/再灌注损伤的新靶点。

Myocardial ischemia/reperfusion injury(MIRI)is the recovery of blood perfusion in myocardial tissue after a long period of ischemia.Instead,it has more obvious and more serious damage and dysfunction than before reperfusion.Recent studies have found that TRPV1 is an important player in the detection of chest pain after myocardial injury,and participate in myocardial ischemia/reperfusion,may play a protective role in MIRI injury,but its mechanism of action is not the same.This article describes that TRPV1 protects against MIRI by improving cardiac function,pathological damage,and myocardial cell damage,as well as reducing free radical release,inhibiting cardiomyocyte apoptosis,reducing inflammatory factor release,and improving mitochondrial function.Mechanisms such as regulation of related factors and signaling pathways are reviewed to investigate the protective effects of TRPV1 in MIRI injury,so as to discover and study new targets for the treatment of myocardial ischemia/reperfusion injury.