麻杏石甘汤加减联合穴位贴敷治疗慢性阻塞性肺疾病急性加重期疗效观察

Observation on Therapeutic Effect of Modified Maxing Shigan Decoction Combined with Acupoint Application on Acute Exacerbation of Chronic Obstructive Pulmonary Disease

目的:探讨麻杏石甘汤加减联合穴位贴敷治疗慢性阻塞性肺疾病急性加重期临床疗效研究。方法:选取2017年1月—2018年12月于医院呼吸科以慢性阻塞性肺疾病急性加重期为诊断门诊治疗的患者84例,随机分为两组:对照组42例,予临床常规治疗;治疗组42例,在对照组常规治疗基础上联合应用麻杏石甘汤和穴位贴敷治疗。观察两组患者治疗前后炎症因子、肺功能、临床疗效和安全性变化,其结果应用统计学软件SPSS19.0进行数据分析。结果:与治疗前相比,治疗后两组患者IL-2、FEV1、FEV1%、FVC、FEV1/FVC水平均升高,IL-8、TNF-α、PCT水平降低;与对照组比较,治疗组患者治疗后IL-2、FEV1、FEV1%、FVC、FEV1/FVC水平均高于对照组,IL-8、TNF-α、PCT水平低于对照组;治疗组患者的总有效率(90.48%)明显高于对照组(78.57%),以上结果差异均有统计学意义(P<0.05)。两组之间不良反应发生率无统计学差异(P>0.05)。结论:麻杏石甘汤加减联合穴位贴敷对慢性阻塞性肺疾病急性加重期患者具有较好的临床疗效,且安全性较高,值得临床推广应用。

Objective:To investigate the clinical effect of modified Maxing Shigan Decoction combined with Acupoint Application on acute exacerbation of chronic obstructive pulmonary disease.Methods:84 patients with acute exacerbation of chronic obstructive pulmonary disease(COPD)in our respiratory department from January 2017 to December 2018 were randomly divided into two groups:42 patients in the control group were treated with routine clinical treatment,and 42 patients in the treatment group were treated with Maxing Shigan Decoction and Acupoint Application on the basis of routine treatment in the control group.Inflammatory factors,pulmonary function,clinical efficacy and safety of the two groups were observed before and after treatment.The results were analyzed by statistical software SPSS19.0.Result:Compared with before treatment,the levels of IL-2,FEV1,FEV1,FVC,FEV1/FVC increased and the levels of IL-8,TNF-a and PCT decreased in the two groups after treatment.Compared with the control group,the levels of IL-2,FEV1,FEV1,FVC,FEV1/FVC in the treatment group were higher than those in the control group,and the levels of IL-8,TNF-a and PCT in the treatment group were lower than those in the control group;the total effective rate of the treatment group(90.48%)was significantly higher than that in the control group.The control group(78.57%)had statistical significance(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Modified Maxing Shigan Decoction combined with acupoint application has good clinical efficacy and safety for patients with acute exacerbation of chronic obstructive pulmonary disease,which is worthy of clinical application.