哈氏促排方对多囊卵巢综合征患者子宫内膜容受性和妊娠结局的影响

Effect of Hashi Cupai Decoction(哈氏促排方)on Endometrial Receptivity and Pregnancy Outcome in Patients with Polycystic Ovary Syndrome

目的分析哈氏促排方对多囊卵巢综合征患者子宫内膜容受性和妊娠结局的影响。方法将医院2018年5月至2020年5月诊治的多囊卵巢综合征患者56例进行研究。按照随机数表法分成对照组和中药组,每组28例。对照组给予常规西药治疗,观察组在对照组基础上加用哈氏促排方(滋肾育泡汤、活血理气促排卵汤、温肾黄体汤)序贯治疗,两组均治疗3个疗程并随访1年。比较两组患者的一般资料、治疗有效率、中医证候评分、子宫内膜容受性指标、妊娠结局相关指标和药物不良反应发生率。结果纳入研究的患者中,对照组有3例病例脱落,剩余25例;中药组有2例病例脱落,剩余26例。中药组治疗有效率、妊娠率和生产率高于对照组(P<0.05);中药组早期流产率和不良反应发生率低于对照组(P<0.05);两组治疗后排卵率对比差异无统计学意义(P>0.05)。两组治疗后中医症状评分、T、LH和E均低于治疗前(P<0.05),且中药组低于对照组(P<0.05);两组治疗后FSH高于治疗前(P<0.05),且中药组高于对照组(P<0.05);两组治疗后子宫内膜厚度、子宫内膜容积、PI和RI高于治疗前(P<0.05),且中药组高于对照组(P<0.05)。结论自拟促排卵方不仅提高了多囊卵巢综合征患者的子宫内膜容受性和妊娠率,提高了生产率,减少药物不良反应发生率,临床安全性高,值得推广。

Objective To observe the Effect of Hashi Cupai Decoction(哈氏促排方)on endometrial receptivity and pregnancy outcome in patients with polycystic ovary syndrome.Methods A total of 56 patients with polycystic ovary syndrome treated in the hospital from May 2018 to May 2020 were studied.According to the random number table method,the patients were divided into control group and traditional Chinese medicine group,28 cases in each group.The control group received conventional western medicine treatment and the observation group received sequential treatment with traditional Chinese medicine on the basis of the control group.Both groups received 3 courses of treatment and followed up for 1 year.The general data,effective rate of treatment,TCM syndrome score,endometrial receptivity index,pregnancy outcome related index and adverse drug reaction rate were compared between the two groups.Results Among the patients included in the study,there were 3 cases of abscission in the control group and 25 cases remained.In the observation group,2 cases fell off and 26 cases remained.The effective rate,pregnancy rate and productivity of the traditional Chinese medicine group were higher than those of the control group(P<0.05).The rate of early abortion and adverse reaction in the traditional Chinese medicine group was lower than that in the control group(P<0.05).There was no statistically significant difference in ovulation rate between the two groups after treatment(P>0.05).After treatment,the scores of TCM symptoms,T,LH and E2 in both groups were lower than those before treatment(P<0.05)and those of the traditional Chinese medicine group was lower than those of the control group(P<0.05).After treatment,FSH in both groups was higher than that before treatment(P<0.05),and FSH in the traditional Chinese medicine group was higher than that in the control group(P<0.05).After treatment,endometrial thickness,endometrial volume,PI and RI in the two groups were higher than those before treatment(P<0.05),and those of the traditional Chinese medicine group were higher than those of the control group(P<0.05).Conclusion The self-designed Hashi Cupai Decoction not only improves the endometrial receptivity and pregnancy rate of patients with polycystic ovary syndrome,but also reduces the early abortion rate and the incidence of adverse drug reactions.It is clinically safe and worthy of promotion.