扶正解毒通络法联合射频消融术治疗原发性肝癌的疗效观察

Efficacy Observation of Strengthening Vital Qi, Reliving Toxin and Dredging Collaterals Method Combined with Radiofrequency Ablation in Treatment of Primary Liver Cancer

目的探讨扶正解毒通络法联合射频消融术对原发性肝癌患者免疫功能、肿瘤转移及生活质量的影响。方法选取2019年10月—2020年7月该院收治的原发性肝癌患者90例,将90例患者随机分为对照组和治疗组,对照组接受经皮射频消融术治疗,治疗组在对照组的基础上联合扶正解毒通络法治疗,两组患者进行为期4周的治疗。观察两组患者中医证候积分、免疫功能指标、血清生长因子指标及生活质量评分的改变情况,并比较两组临床疗效。结果对比两组中医证候积分变化,治疗组患者证候积分降低较对照组更为显著,结果具差异有统计学意义(P<0.05);对比两组患者免疫功能指标,两组患者均有所改善,且治疗组效果更加显著(P<0.05),说明治疗组可有效增强机体免疫力;对比两组患者血清生长因子水平,两组患者治疗后血清生长因子水平均低于治疗前,且治疗组更为显著,有统计学意义(P<0.05);对比两组患者功能状态评分标准(KPS)变化,治疗组KPS评分水平明显高于对照组,差异有统计学意义(P<0.05);治疗后,治疗组临床总有效率为91.11%(41/45),对照组临床总有效率为75.56%(34/45),治疗组较对照组改善明显,结果具差异有统计学意义(P<0.05)。结论扶正解毒通络法具有扶正益气,活血化瘀,通络解毒之效,联合射频消融术可以有效改善原发性肝癌患者临床症状和体征,能够增强机体免疫力、抑制肿瘤转移,改善患者生活质量,对于原发性肝癌患者有较好的的治疗效果,值得临床推广应用。

Objective The purpose of this study was to explore the effect of strengthening vital Qi,reliving toxin and dredging collaterals method combined with radiofrequency ablation on immune function,tumor metastasis and life-quality of patients with primary HCC.Methods The information of patients with primary HCC diagnosed and treated in our hospital from October 2019 to July 2020 was collected.After screening,90 eligible patients were randomly divided into two groups according to the random number table method,of which 45 patients in the control group(group A)were treated with percutaneous radiofrequency ablation(Scheme A)and 45 patients in the treatment group(group B)were treated with strengthening vital Qi,reliving toxin and dredging collaterals method combined with Scheme A(Scheme B).The treatment course was 4 weeks.The observation indexes included the changes of TCM syndrome integral,immune function index and life-quality score in the two groups.The clinical efficacy of the two groups was compared.Results The TCM syndrome score decrease of group B was more obvious than that in the group A,and the results were significantly different(P<0.05).The content of immune function index of both groups were improved,and the treatment effect of group B was more significant(P<0.05).It showed that the method used in group B can effectively enhance the immunity of the body.After treatment,the VEGF level of the two groups was lower than that before treatment,and the VEGF level of group B was significantly lower than that of group A(P<0.05).The KPS score level of the group B was significantly higher than that of the group A,and the difference was statistically significant(P<0.05).The clinical efficacy of the treatment group was better than that of the control group[91.11%(41/45)vs.75.56%(34/45)].Conclusion Strengthening vital Qi,reliving toxin and dredging collaterals method has the effects of strengthening body resistance,invigorating Qi,improving blood circulation and dispersing blood stasis,dredging collaterals and relieving toxin.This method combined with radiofrequency ablation can effectively improve the clinical symptoms and signs of patients with primary HCC,enhance the immunity of the body,inhibit tumor metastasis and improve the life-quality of patients.It has a good therapeutic effect on patients with primary HCC and is worthy of clinical application.