补肾益胎汤辅助治疗对先兆流产孕妇母婴结局的影响研究

Effects of Bushen Yitai Decoction(补肾益胎汤)Adjuvant Therapy on Maternal-Infant Outcomes of Pregnant Women with Threatened Abortion

目的研究补肾益胎汤辅助治疗对先兆流产孕妇母婴结局的影响。方法将该院160例先兆流产患者随机分为治疗组(n=80)与对照组(n=80),对照组予以地屈孕酮片治疗,治疗组予以补肾益胎汤+地屈孕酮片治疗,治疗疗程14 d,观察两组临床疗效、治疗前后主要中医症状(腰背疼痛、小腹坠痛、阴道出血、两膝酸软)积分、性激素[血绒毛膜促性腺激素(β-HCG)、孕酮、雌二醇(E_(2))]水平以及母婴结局的变化情况,统计两组临床疗效与不良反应。结果治疗组总有效率明显高于对照组(P<0.05);两组治疗后,中医主症症状积分均明显降低(P<0.05),β-HCG,孕酮、E_(2)水平均明显升高(P<0.05),且治疗组治疗后以上各指标改善情况均明显优于对照组(P<0.05);治疗组足月分娩率明显高于对照组(P<0.05),自然流产率明显低于对照组(P<0.05),早产率与对照组比较差异无统计学意义(P>0.05);治疗组足月低体重儿、低Apgar评分新生儿以及呼吸窘迫新生儿与对照组比较,差异无统计学意义(P>0.05)。结论补肾益胎汤辅助治疗先兆流产孕妇疗效明显,可缓解患者临床症状,调节性激素水平,改善母婴结局,提高临床治疗效果,且安全。

Objective To study the effects of Bushen Yitai Decoction(补肾益胎汤)adjuvant therapy on maternal-infant outcomes of pregnant women with threatened abortion.Methods A total of 160 patients with threatened abortion in our hospital were rando mLy divided into treatment group(n=80)and control group(n=80).The control group was treated with dydrogesterone,and the treatment group was treated with Bushen Yitai Decoction and dydrogesterone,and they were treated for 14 d.The clinical efficacy and scores of main TCM symptoms(low back pain,lower abdominal pain,vaginal bleeding,soreness and weakness of two knees),sex hormones[human chorionic gonadotropin(β-HCG),progesterone,estradiol(E_(2))]and maternal-infant outcomes before and after treatment were observed in the two groups,and the clinical efficacy and adverse reactions were counted in the two groups.Results The total effective rate in the treatment group was significantly higher than that in the control group(P<0.05).After treatment,the scores of main TCM symptoms were significantly decreased in the two groups(P<0.05)while the levels ofβ-HCG,progesterone and E_(2) were significantly increased(P<0.05),and the improvements of all the indexes above in the treatment group were significantly better than those in the control group(P<0.05).The full-term delivery rate in the treatment group was significantly higher than that in the control group(P<0.05)while the spontaneous abortion rate was significantly lower than that in the control group(P<0.05),and there was no significant difference in preterm birth rate compared with that in the control group(P>0.05).The full-term low birth weight infants,low Apgar score neonates and respiratory distress neonates in the treatment group were significantly different compared with those in the control group(P>0.05).Conclusion Bushen Yitai Decoction adjuvant therapy has significant efficacy in the treatment of pregnant women with threatened abortion.It can relieve clinical symptoms,regulate sex hormones levels,improve maternal-infant outcomes and promote clinical treatment effects,with safety.