化瘀祛痰颗粒对急性心肌梗死PCI术后无复流患者心功能及心血管事件的影响

Effect of Huayu Qutan Granules(化瘀祛痰颗粒)on Cardiac Function and Cardiovascular Events in Patients with No-Reflow after PCI for Acute Myocardial Infarction

目的探究化瘀祛痰颗粒对急性心肌梗死PCI术后无复流患者心功能及心血管事件的影响。方法以该院2017年10月-2019年10月收治的急性心肌梗死PCI术后无复流患者180例为观察对象,随机分为对照组和试验组,各90例。对照组给予常规西医治疗,试验组在对照组的基础上应用化瘀祛痰颗粒进行治疗,两组患者进行为期1周的治疗,并随访6个月。比较两组患者心功能、西雅图心绞痛量表(SAQ)评分、心血管不良事件及临床疗效。结果治疗后两组心功能指标中射血分数(LVEF)均有所升高(P<0.05),但是试验组升高幅度更显著,结果具有显著差异(P<0.05);治疗后试验组左室舒张末内径(LVEDD)降低,对照组LVEDD升高,结果具有显著差异(P<0.05),组间比较,试验组优于对照组,结果具有显著差异(P<0.05);治疗后两组SAQ相关指标均有所改善(P<0.05),但试验组改善更为明显,结果具有显著差异(P<0.05);随访6个月后,试验组患者心血管不良事件总发生率为2.22%(2/90),显著低于对照组的11.11%(10/90),结果具有显著差异(P<0.05);试验组临床总有效率为95.56%(86/90),对照组临床总有效率为78.89%(71/90),结果具有显著差异(P<0.05)。结论化瘀祛痰颗粒可有效改善急性心肌梗死患者PCI术后无复流者的临床症状,起到健脾益气、化瘀祛痰的作用,增加病灶区域局部心肌细胞微循环灌注量,促进心功能恢复,降低心血管不良事件总发生率,值得临床推广应用。

Objective The purpose of this study was to investigate the effect of Huayu Qutan Granules(化瘀祛痰颗粒)on cardiac function and cardiovascular events in patients with no-reflow(NR)after PCI for acute myocardial infarction.Methods A total of 180 patients with with NR after PCI for acute myocardial infarction admitted to our hospital from October 2017 to October 2019 were taken as observation objects,and they were randomly divided into two groups(i.e.control group and experimental group),with 90 patients in each group.The control group was administered with conventional western treatment,while the treatment group was administered with Huayu Qutan Granules on the basis of the control group.The patients in both groups were treated for 1 week and followed up for 6 months.The cardiac function,Seattle Angina Questionnaire(SAQ)score,adverse cardiovascular events and clinical efficacy of the two groups were compared.Results After treatment,the ejection fraction(LVEF)in the cardiac function indexes of both groups was increased(P<0.05),but the increase in the experimental group was more significant and the results showed significant difference(P<0.05).The left ventricular end diastolic diameter(LVEDD)in the experimental group was decreased while that in the control group increased after treatment.The difference between the two groups was statistically significant(P<0.05).Compared with that of the control group,the curative effect of the experimental group was better,with significant difference(P<0.05).After treatment,SAQ-related indexes in both groups were improved(P>0.05),but the improvement was more obvious in the experimental group,with significant difference in results(P<0.05).After 6 months of follow-up,the total incidence of cardiovascular adverse events was 2.22%(2/90)in the experimental group,which was significantly lower than that in the control group(11.11%,10/90).The difference between the two groups was statistically significant(P<0.05).The total clinical effective rate of the treatment group was 95.56%(86/90),which was significantly higher than that of the control group(78.89%,71/90)(P<0.05).Conclusion Huayu Qutan Granules can effectively improve the clinical symptoms of patients with acute myocardial infarction who have NR after PCI,play the roles of strengthening spleen and replenishing Qi,removing blood stasis and reducing phlegm,increase the microcirculation perfusion of local myocardial cells in the focus area,promote the recovery of cardiac function,and reduce the total incidence of cardiovascular adverse events.It is worthy of clinical promotion and application.