中西医理论对帕金森便秘发病机制的探讨

Discussion on Pathogenesis of Parkinson′s Disease Constipation by Theory of Traditional Chinese and Western Medicine

帕金森病是一种渐进发展的中枢神经系统退行性性疾病,当前医学界大多数主要集中在PD的临床期,而实际上,PD非运动症状在疾病早期占据更重要的地位,其中以胃肠功能紊乱为主要代表的便秘症状不仅持续时间最长,有的甚至早于PD确诊前20年以上[1]。由于各种因素导致α-突触核蛋白在肠神经系统中异常沉积,并且部分逐渐逆传至中枢神经系统进行沉积,致使PD前期出现便秘症状。该文还从脑肠相关理论,阐明帕金森便秘的机制探讨,总的目的在于从中西医结理论对帕金森非运动症状便秘的发病机制进行探究,为未来治疗PD提供思路。

Parkinson′s disease(PD)is a progressive development of the central nervous system degenerative disease,most of the current medical community is mainly concentrated in the clinical stage of PD.But in fact,PD non-motor symptoms occupy a more important position in the early stage of the disease,among which the constipation symptoms represented by gastrointestinal dysfunction are not only the longest,some are more than 20 years before the diagnosis of PD[1].Due to various factors leading to abnormal deposition ofα-synuclein in the intestinal nervous system,and partial reverse transmission to the central nervous system for deposition,resulting in constipation symptoms in the early stage of PD.This article also expounded the mechanism of Parkinson′s disease constipation from the theory of brain and intestine,the general purpose of which is to explore the pathogenesis of Parkinson′s disease non-motor constipation from the theory of traditional Chinese and western medicine,and provide ideas for the future treatment of PD.