银杏叶提取物联合当归穴位注射对脑梗死患者血清SOD和MDA水平的影响

Effect of Ginkgo Biloba Extract Combined with Danggui(Angelica) Acupoint Injection on Serum Levels of SOD and MDA in Patients with Cerebral Infarction

目的探究EGb联合当归穴位注射对脑梗死患者血清SOD和MDA水平的影响。方法选取2014年1月—2018年1月该院收治的脑梗死患者200例,将其随机分为对照组(n=100)和观察组(n=100)。对照组给予常规西医治疗,观察组在对照组基础上应用EGb联合当归穴位注射治疗,两者患者均治疗15 d。统计两组患者治疗后的临床疗效、治疗前后MESSS和Barthel评分、血清水平(包括SOD、NDA、NO)、治疗期间不良反应情况。结果治疗后观察组、对照组临床总有效率分别为94.00%(94/100)、83.00%(83/100),差异有统计学意义(P<0.05);治疗后两组患者MESSS评分下降、Barthel评分升高,观察组显著低(高)于对照组(P<0.01或P<0.05);治疗后两组患者SOD、NO水平升高,MDA水平下降,观察组高(低)于对照组(P<0.01);治疗期间两组患者的不良反应发生率的比较差异无统计学意义(P>0.05)。结论EGb联合当归穴位注射治疗脑梗死可以有效改善患者临床症状,改善患者血清SOD和MDA水平,保护缺血损伤的脑组织,且不良反应小、安全有效,有利于临床推广。

Objective To explore the effects of Ginkgo biloba extract(EGb)combined with Danggui(Angelica)acupoint injection on serum levels of SOD and MDA in patients with cerebral infarction.Methods A total of 200 patients with cerebral infarction admitted to our hospital from January 2014 to January 2018 were divided into control group(n=100)and observation group(n=100)according to random number table method.The control group was treated with conventional Western medicine,while the observation group was treated with EGb combined with Danggui(Angelica)acupoint injection on the basis of the control group.Both patients were treated for 15 days.The observation group was treated with EGb on the basis of the control group.Both patients were treated for 15 days.The clinical efficacy,MESSS and Barthel scores,serum levels(including SOD,NDA,NO)and adverse reactions during treatment were compared between the two groups.Results After treatment,the total clinical effective rates of the observation group and the control group were 94.00%(94/100)and 83.00%(83/100),respectively,with statistical significance(P<0.05).After treatment,MESSS score of the two groups decreased and Barthel score increased,while that of the observation group was significantly lower(higher)than that of the control group(P<0.01 or P<0.05).After treatment,the levels of SOD and NO increased and MDA decreased in the two groups.The levels of SOD and NO in the observation group were higher(lower)than those in the control group(P<0.01).There was no statisticalsignificant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion EGb combined with Danggui(Angelica)acupoint injection in the treatment of cerebral infarction can effectively improve the clinical symptoms of patients and the serum levels of SOD and MDA,protect the brain tissue of ischemic injury,and the adverse reactions are few.It is safe and effective and is conducive to clinical promotion.